ArticlePlant direct2018
A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch.
Article in Plant direct, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- Large-scale transcriptome mining enables macrocyclic diversification and improved bioactivity of the stephanotic acid scaffold.Nature communications · 2025Article
- Plant peptides - redefining an area of ribosomally synthesized and post-translationally modified peptides.Natural product reports · 2024Review
- Probing of plant transcriptomes reveals the hidden genetic diversity of the family Secoviridae.Archives of virology · 2024Article
- The flax genome reveals orbitide diversity.BMC genomics · 2022Article
- Inhibition of chloroplast translation as a new target for herbicides.RSC chemical biology · 2022Article
- Hololectin Interdomain Linker Determines Asparaginyl Endopeptidase-Mediated Maturation of Antifungal Hevein-Like Peptides in Oats.Frontiers in plant science · 2022Article
- The legumain McPAL1 from Momordica cochinchinensis is a highly stable Asx-specific splicing enzyme.The Journal of biological chemistry · 2021Article
- Plant derived cyclic peptides.Biochemical Society transactions · 2021Review
- Plant asparaginyl endopeptidases and their structural determinants of function.Biochemical Society transactions · 2021Review
- A chameleonic macrocyclic peptide with drug delivery applications.Chemical science · 2021Article
- The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides.The Journal of biological chemistry · 2020Article
- Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides.Journal of industrial microbiology & biotechnology · 2020Review
- A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch.Plant direct · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Orbitides are cyclic ribosomally-synthesized and post-translationally modified peptides (RiPPs) from plants; they consist of standard amino acids arranged in an unbroken chain of peptide bonds. These cyclic peptides are stable and range in size and topologies making them potential scaffolds for peptide drugs; some display valuable biological activities. Recently two orbitides whose sequences were buried in those of seed storage albumin precursors were said to represent the first observable step in the evolution of larger and hydrophilic bicyclic peptides. Here, guided by transcriptome data, we investigated peptide extracts of 40 species specifically for the more hydrophobic orbitides and confirmed 44 peptides by tandem mass spectrometry, as well as obtaining solution structures for four of them by NMR. Acquiring transcriptomes from the phylogenetically important Corymboideae family confirmed the precursor genes for the peptides (called
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.