Evidence map›Paper›PMID 30417113›Full record

ArticlemSystems

Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria.

Egle Cekanaviciute, Anne-Katrin Pröbstel, Anna Thomann, Tessel F Runia, Patrizia Casaccia, Ilana Katz Sand, Elizabeth Crabtree, Sneha Singh, John Morrissey, Patrick Barba and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. The Gut Microbiome in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2026
    Review
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  7. Article
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  11. Article
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  20. Role ofNutrients · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Egle CekanaviciuteUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Anne-Katrin PröbstelUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Anna ThomannUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Tessel F RuniaUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Patrizia CasacciaIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Ilana Katz SandIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Elizabeth CrabtreeUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Sneha SinghUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
John MorrisseyUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Patrick BarbaUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Refujia GomezUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Rob KnightUniversity of California San Diego, San Diego, California, USA.
Sarkis MazmanianCalifornia Institute of Technology, Pasadena, California, USA.
Jennifer GravesUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Bruce A C CreeUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Scott S ZamvilUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.
Sergio E BaranziniUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-0067-194X
University of California, San Francisco · USCalifornia Institute of Technology · USIcahn School of Medicine at Mount Sinai · USThe Graduate Center, CUNY · USUniversity of California San Diego · US

Funding

UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4M
Influence of NMO gut microbiota on CNS autoantigen-specific T cell responsesR21NS108159 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2018 to 2019
$451k
NIGMS NIH HHS K12 GM081266NINDS NIH HHS R21 NS108159
6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by adaptive and innate immune system dysregulation. Recent work has revealed moderate alteration of gut microbial communities in subjects with MS and in experimental, induced models. However, a mechanistic understanding linking the observed changes in the microbiota and the presence of the disease is still missing. Chloroform-resistant, spore-forming bacteria, which primarily belong to the classes

Indexed as

immune mechanismsmultiple sclerosisspore-forming bacteria

Identifiers

PMID30417113
PMCPMC6222044
OpenAlexW2807644906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.