Evidence map›Paper›PMID 30417103›Full record

ArticleAIMS genetics2018

Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm.

Sarah M Zimmerman, Roberta Besio, Melissa E Heard-Lipsmeyer, Milena Dimori, Patrizio Castagnola, Frances L Swain, Dana Gaddy, Alan B Diekman, Roy Morello

Open access · diamondAbstract read
In one paragraph

Article in AIMS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sarah M ZimmermanDepartment of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Roberta BesioDepartment of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Melissa E Heard-LipsmeyerDepartment of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Milena DimoriDepartment of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Patrizio CastagnolaIRCSS AOU-San Martino-IST, Genoa, Italy.
Frances L SwainDepartment of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Dana GaddyDepartment of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Alan B DiekmanDepartment of Biochemistry, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Roy MorelloDepartment of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
University of Arkansas for Medical Sciences · USOspedale Policlinico San Martino · IT

Funding

Expanding Translational Research in ArkansasU54TR001629 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2017 to 2017
$3.5M
Role of the Leprecan Genes in Skeletal FormationR01AR060823 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI MORELLO, ROY · 2012 to 2016
$1.6M
NCATS NIH HHS U54 TR001629NIAMS NIH HHS R01 AR060823
6 · The paper itself

Abstract

The Leprecan protein family which includes the prolyl 3-hydroxylase enzymes (P3H1, P3H2, and P3H3), the closely related cartilage-associated protein (CRTAP), and SC65 (Synaptonemal complex 65, aka P3H4, LEPREL4), is involved in the post-translational modification of fibrillar collagens. Mutations in

Indexed as

CRTAPLeprecansovarySC65sperm morphologytestis

Identifiers

PMID30417103
PMCPMC6221197
OpenAlexW2787618303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.