ArticleScience advances2018
The optimal mating distance resulting from heterosis and genetic incompatibility.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Genetics and genomics of hybridization.Nature reviews. Genetics · 2026Review
- Intraspecific Hybridization Improves Performance of the Biological Control AgentEvolutionary applications · 2026Article
- Genetic recombination shapes complex hybrid effects across the pig genome.National science review · 2026Article
- Analysis of trait differences and identification of superior early growth combinations in interspecific hybrid progenies of Gleditsia sinensis.BMC plant biology · 2026Article
- A novel genetic framework reveals transcriptional "butterfly effect" underlying heterosis in maize.Journal of advanced research · 2026Article
- Article
- From Individual to Stand Performance in Hybrids: Challenging the Optimal Parental Genetic Distance.Evolutionary applications · 2025Article
- Analysis of Growth Models in Galician × Nelore Crossbred Cattle in the First Year of Life.Animals : an open access journal from MDPI · 2024Article
- Maximization through optimization? On the relationship between hybrid performance and parental genetic distance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
- Transcriptional misexpression in hybrids between species linked by gene flow is associated with patterns of sequence divergence.Genome biology and evolution · 2023Article
- Article
- What Has Genomics Taught An Evolutionary Biologist?Genomics, proteomics & bioinformatics · 2023Review
- The diverse effects of phenotypic dominance on hybrid fitness.Evolution; international journal of organic evolution · 2022Article
- Photosynthetic Efficiency and Glyco-Metabolism Changes in Artificial Triploid Loquats Contribute to Heterosis Manifestation.International journal of molecular sciences · 2022Article
- Heterosis counteracts hybrid breakdown to forestall speciation by parallel natural selection.Proceedings. Biological sciences · 2022Article
- Environment-Dependent Heterosis and Transgressive Gene Expression in Reciprocal Hybrids between the Channel CatfishBiology · 2022Article
- Epistasis Activation Contributes Substantially to Heterosis in Temperate by Tropical Maize Hybrids.Frontiers in plant science · 2022Article
- Improved redox homeostasis owing to the up-regulation of one-carbon metabolism and related pathways is crucial for yeast heterosis at high temperature.Genome research · 2021Article
- Negative dominance and dominance-by-dominance epistatic effects reduce grain-yield heterosis in wide crosses in wheat.Science advances · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Theory predicts that the fitness of an individual is maximized when the genetic distance between its parents (i.e., mating distance) is neither too small nor too large. However, decades of research have generally failed to validate this prediction or identify the optimal mating distance (OMD). Respectively analyzing large numbers of crosses of fungal, plant, and animal model organisms, we indeed find the hybrid phenotypic value a humped quadratic polynomial function of the mating distance for the vast majority of fitness-related traits examined, with different traits of the same species exhibiting similar OMDs. OMDs are generally slightly greater than the nucleotide diversities of the species concerned but smaller than the observed maximal intraspecific genetic distances. Hence, the benefit of heterosis is at least partially offset by the harm of genetic incompatibility even within species. These results have multiple theoretical and practical implications for speciation, conservation, and agriculture.
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