ArticleScience advances2018
An ancient Turing-like patterning mechanism regulates skin denticle development in sharks.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 87 citations in OpenAlex.
- Lateral inhibition governs ancestral cellular patterning in fossil and extant liverworts.Development (Cambridge, England) · 2026Article
- Teeth outside the jaw: Evolution and development of the toothed head clasper in chimaeras.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Synthetic Forms Most Beautiful: Engineering Insights into Self-Organization.Physiology (Bethesda, Md.) · 2025Review
- Chemical and mechanical patterning of tortoise skin scales occur in different regions of the head.iScience · 2025Article
- Exacerbated sonic hedgehog signalling promotes a transition from chemical pre-patterning of chicken reticulate scales to mechanical skin folding.Open biology · 2025Article
- In vivo sonic hedgehog pathway antagonism temporarily results in ancestral proto-feather-like structures in the chicken.PLoS biology · 2025Article
- Opposing roles for Bmp signalling during the development of electrosensory lateral line organs.eLife · 2025Article
- Quantifying the Denticle Multiverse: A Standardized Coding System to Capture Three Dimensional Morphological Variations for Quantitative Evolutionary and Ecological Studies of Elasmobranch Denticles.Integrative organismal biology (Oxford, England) · 2025Article
- Article
- Anatomy, development and regeneration of zebrafish elasmoid scales.Developmental biology · 2024Article
- Gap junctions in Turing-type periodic feather pattern formation.PLoS biology · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Development shapes the evolutionary diversification of rodent stripe patterns.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo.Science advances · 2023Article
- A shark-inspired general model of tooth morphogenesis unveils developmental asymmetries in phenotype transitions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Leafy and weedy seadragon genomes connect genic and repetitive DNA features to the extravagant biology of syngnathid fishes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates.eLife · 2022Article
- Redeployment of odontode gene regulatory network underlies dermal denticle formation and evolution in suckermouth armored catfish.Scientific reports · 2022Article
- Evolved Bmp6 enhancer alleles drive spatial shifts in gene expression during tooth development in sticklebacks.Genetics · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrates have a vast array of epithelial appendages, including scales, feathers, and hair. The developmental patterning of these diverse structures can be theoretically explained by Alan Turing's reaction-diffusion system. However, the role of this system in epithelial appendage patterning of early diverging lineages (compared to tetrapods), such as the cartilaginous fishes, is poorly understood. We investigate patterning of the unique tooth-like skin denticles of sharks, which closely relates to their hydrodynamic and protective functions. We demonstrate through simulation models that a Turing-like mechanism can explain shark denticle patterning and verify this system using gene expression analysis and gene pathway inhibition experiments. This mechanism bears remarkable similarity to avian feather patterning, suggesting deep homology of the system. We propose that a diverse range of vertebrate appendages, from shark denticles to avian feathers and mammalian hair, use this ancient and conserved system, with slight genetic modulation accounting for broad variations in patterning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.