Evidence map›Paper›PMID 30417093›Full record

ArticleScience advances2018

Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations.

Jaesung P Choi, Rui Wang, Xi Yang, Xian Wang, Lu Wang, Ka Ka Ting, Matthew Foley, Victoria Cogger, Zhuo Yang, Feng Liu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Endothelial estrogen receptor alpha (ESR1) regulates cerebral cavernous malformation pathogenesis via MEKK3-KLF signaling pathway.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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  18. Characteristics of intestinal flora in patients with cerebral infarction complicated with Type 2 diabetes mellitus.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Jaesung P ChoiLaboratory of Cardiovascular Signaling, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.ORCID 0000-0002-0135-8632
Rui WangDepartment of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.ORCID 0000-0002-1966-0485
Xi YangDepartment of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.ORCID 0000-0002-2386-267X
Xian WangLaboratory of Cardiovascular Signaling, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.ORCID 0000-0001-6342-2700
Lu WangInstitute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0003-4788-3237
Ka Ka TingCentre for the Endothelium, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.
Matthew FoleyAustralian Centre for Microscopy & Microanalysis, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-4077-445X
Victoria CoggerANZAC Research Institute, University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-6346-9928
Zhuo YangShanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0001-6037-0319
Feng LiuInstitute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0003-3228-0943
Zhiming HanInstitute of Zoology, Chinese Academy of Sciences, Beijing, China.
Renjing LiuAgnes Ginges Laboratory for Diseases of the Aorta, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.
Jonathan BaellMonash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Xiangjian ZhengLaboratory of Cardiovascular Signaling, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.ORCID 0000-0001-6277-5168
Centenary Institute · AUChinese Academy of Sciences · CNThe University of Sydney · AUTianjin Medical University · CNMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral cavernous malformation (CCM) is a common cerebrovascular disease that can occur sporadically or be inherited. They are major causes of stroke, cerebral hemorrhage, and neurological deficits in the younger population. Loss-of-function mutations in three genes,

Indexed as

AnimalsCells, CulturedDisease ProgressionEndothelium, VascularGene Expression RegulationImidazolesIntellectual DisabilityKRIT1 ProteinKruppel-Like Transcription FactorsMAP Kinase Kinase Kinase 3MiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMicrognathismMutationerythroid Kruppel-like factorImidazolesKRIT1 ProteinKrit1 protein, mouseKruppel-Like Transcription FactorsMap3k3 protein, mouseMAP Kinase Kinase Kinase 3Microfilament Proteinsosmosensing scaffold for MEKK3 protein, mouseponatinibProtein Kinase InhibitorsPyridazines

Identifiers

PMID30417093
PMCPMC6221540
OpenAlexW2899540440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.