Evidence map›Paper›PMID 30417035›Full record

ArticleOptica2018

Highly parallel, interferometric diffusing wave spectroscopy for monitoring cerebral blood flow dynamics.

Wenjun Zhou, Oybek Kholiqov, Shau Poh Chong, Vivek J Srinivasan

Open access · goldAbstract read
In one paragraph

Article in Optica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wenjun ZhouDepartment of Biomedical Engineering, University of California Davis, Davis, California 95616, USA.
Oybek KholiqovDepartment of Biomedical Engineering, University of California Davis, Davis, California 95616, USA.
Shau Poh ChongDepartment of Biomedical Engineering, University of California Davis, Davis, California 95616, USA.
Vivek J SrinivasanDepartment of Biomedical Engineering, University of California Davis, Davis, California 95616, USA.
University of California, Davis · US

Funding

Imaging Neuronal and Capillary Dysfunction Deep in the Rodent Brain in vivo Using 1700 NM Optical Coherence Microscopy and Tracer-Based KineticsR01NS094681 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2015 to 2019
$1.6M
Development, Validation and Application of Metabolic Imaging in GlaucomaR01EY028287 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO, GOLDBERG, JEFFREY L · 2017 to 2019
$1.1M
Interferometric Near-Infrared Spectroscopy for Tissue Flowmetry and OximetryR21NS105043 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2017 to 2018
$432k
Improving penetration depth and spatial resolution for in vivo deep imaging of mouse brain using 2200 nm Optical Coherence MicroscopyR03EB023591 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2017 to 2018
$157k
NEI NIH HHS R01 EY028287NIBIB NIH HHS R03 EB023591NINDS NIH HHS R01 NS094681NINDS NIH HHS R21 NS105043
6 · The paper itself

Abstract

Light-scattering methods are widely used in soft matter physics and biomedical optics to probe dynamics in turbid media, such as diffusion in colloids or blood flow in biological tissue. These methods typically rely on fluctuations of coherent light intensity, and therefore cannot accommodate more than a few modes per detector. This limitation has hindered efforts to measure deep tissue blood flow with high speed, since weak diffuse light fluxes, together with low single-mode fiber throughput, result in low photon count rates. To solve this, we introduce multimode fiber (MMF) interferometry to the field of diffuse optics. In doing so, we transform a standard complementary metal-oxide-semiconductor (CMOS) camera into a sensitive detector array for weak light fluxes that probe deep in biological tissue. Specifically, we build a novel CMOS-based, multimode interferometric diffusing wave spectroscopy (iDWS) system and show that it can measure ∼

Indexed as

(030.4070) Modes(060.0060) Fiber optics and optical communications(120.6160) Speckle interferometry(170.0170) Medical optics and biotechnology(290.4210) Multiple scattering

Identifiers

PMID30417035
PMCPMC6226099
OpenAlexW2801251212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.