Evidence map›Paper›PMID 30417015›Full record

ArticleBioMed research international2018

Low Performance of a Clinical-Genetic Model in the Estimation of Time in Therapeutic Range in Acenocoumarol-Adherent Patients with Nonvalvular Atrial Fibrillation: The Quality of Anticoagulation Challenge.

Samantha Wasniewski, Luciano Consuegra-Sánchez, Pablo Conesa-Zamora, Luis García de Guadiana-Romualdo, Pablo Ramos-Ruiz, Marta Merelo-Nicolás, F Guillermo Clavel-Ruipérez, Begoña Alburquerque-González, Federico Soria-Arcos, Juan A Castillo-Moreno

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Effect of SAMe-TTJournal of thrombosis and thrombolysis · 2020
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Samantha WasniewskiDepartment of Cardiology, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.ORCID 0000-0002-8193-6518
Luciano Consuegra-SánchezDepartment of Cardiology, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.ORCID 0000-0002-1367-4173
Pablo Conesa-ZamoraDepartment of Clinical Analysis, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.
Luis García de Guadiana-RomualdoDepartment of Clinical Analysis, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.
Pablo Ramos-RuizDepartment of Cardiology, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.
Marta Merelo-NicolásDepartment of Cardiology, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.
F Guillermo Clavel-RuipérezDepartment of Cardiology, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.
Begoña Alburquerque-GonzálezFaculty of Health Sciences, UCAM Catholic University San Antonio of Murcia, Spain.
Federico Soria-ArcosDepartment of Cardiology, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.
Juan A Castillo-MorenoDepartment of Cardiology, Santa Lucía General University Hospital, Cartagena-Murcia, Spain.
Santa Lucía University General Hospital · ESUniversidad Católica de Murcia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnticoagulation with vitamin K antagonists continues to be a challenging task given the difficulty of achieving a correct time in therapeutic range (TTR). The SAMeTT

methodsWe prospectively included 212 consecutive patients with nonvalvular atrial fibrillation under treatment with acenocoumarol for at least 6 months that were attended in a cardiology outpatient clinic and were categorized as adherent to medication. We carried out a multivariate regression analysis to detect the independent predictive factors of good control. In all patients

resultsA total of 128 (60.4%) patients presented TTR <70% (average TTR = 63.2). We identified body mass index (OR 0.94, 95%CI 0.89-0.99, p=0.032) and regular vitamin K intake (OR 0.53, 95%CI 0.28-0.99, p= 0.046) as independent predictors of poor anticoagulation control. The discriminatory power of a clinical-genetic model derived from our cohort was significantly better compared to the SAMeTT

conclusionsIn our study the SAMeTT

Indexed as

AcenocoumarolAgedAnticoagulantsAtrial FibrillationBlood CoagulationBody Mass IndexFemaleHumansMaleModels, GeneticMultivariate AnalysisProspective StudiesVitamin KAcenocoumarolAnticoagulantsVitamin K

Identifiers

PMID30417015
PMCPMC6207892
OpenAlexW2896705611

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.