Observational studyBioMed research international2018
Manifestations and Outcomes of Patients with Parkinson's Disease and Serious Infection in the Emergency Department.
Observational study in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Microbial Trojan Horses: Virulence Factors as Key Players in Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2025Review
- Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease.EMBO molecular medicine · 2024Article
- Oh my gut! Is the microbial origin of neurodegenerative diseases real?Infection and immunity · 2023Review
- More than medications: a patient-centered assessment of Parkinson's disease care needs during hospitalization.Frontiers in aging neuroscience · 2023Article
- Mortality and causes of death in patients with Parkinson's disease: a nationwide population-based cohort study.Frontiers in neurology · 2023Article
- Impaired migratory phenotype of CD4NPJ Parkinson's disease · 2022Article
- Association between Parkinson's Disease Medication and the Risk of Lower Urinary Tract Infection (LUTI): A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Probiotics and the Treatment of Parkinson's Disease: An Update.Cellular and molecular neurobiology · 2022Review
- Urinary Tract Infection in Parkinson's Disease.Journal of Parkinson's disease · 2022Review
- Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate.PLoS pathogens · 2021Article
- The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson's disease?Neural regeneration research · 2021Article
- Effects of the probiotic formulation SLAB51 inAging · 2020Article
- Innate immune responses to paraquat exposure in a Drosophila model of Parkinson's disease.Scientific reports · 2019Article
- Probiotics May Have Beneficial Effects in Parkinson's Disease:Frontiers in immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral comorbidities contribute to an increased risk of infections in Parkinson's disease (PD) as the disease progresses. However, few studies have examined the correlation between sepsis and PD.
aimThe aim of this study is to disclose the presentation and outcome of serious infection in patients with PD in the emergency department.
methodsThis retrospective cohort study enrolled patients with PD who had serious infection and were admitted to the emergency department between January 2007 and December 2013. For clinical comparison, we compared the clinical features, laboratory data, and outcomes with those of age- and sex-matched patients who had serious infection but not PD.
resultsThere were a total of 1,200 episodes of infected PD patients and 2,400 age- and sex-matched infected patients without PD as disease controls. PD patients had fewer comorbidities and lower severity of infectious disease but longer hospital stays than control group patients. The incidences of respiratory tract and urinary tract infections were higher in PD patients. The levels of inflammatory and organ dysfunction biomarkers in PD were lower and compatible with the severity of infectious disease. A total of 86 (7.2%) infected PD patients died during the 28-day admission compared to 339 (14.1%) in non-PD patients. Serum C-reactive protein, bandemia, and lactate could be used to predict mortality in infected PD patients.
conclusionsIn infected patients with PD, respiratory and urinary tract infections were the two most common infectious sources. Empiric therapy based on experience could treat both respiratory and urinary tract infections. Early diagnosis and treatment are essential for survival.
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