Evidence map›Paper›PMID 30416933›Full record

ArticleCurrent transplantation reports2018

Posttransplant Medical Adherence: What Have We Learned and Can We Do Better?

Mary Amanda Dew, Donna M Posluszny, Andrea F DiMartini, Larissa Myaskovsky, Jennifer L Steel, Annette J DeVito Dabbs

Open access · greenAbstract read
In one paragraph

Article in Current transplantation reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

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  5. Population Health Management for Improving Kidney Health Outcomes.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mary Amanda DewDepartment of Psychiatry, University of Pittsburgh School of Medicine and Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Donna M PoslusznyDepartment of Medicine and University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Andrea F DiMartiniDepartments of Psychiatry and Surgery and the Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Larissa MyaskovskyDepartment of Internal Medicine, Nephrology Division, and the Center for Healthcare Equity in Kidney Disease, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
Jennifer L SteelDepartments of Surgery, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Annette J DeVito DabbsDepartment of Acute and Tertiary Care, School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USUniversity of New Mexico · USUniversity of Pittsburgh Medical Center · USUPMC Hillman Cancer Center · US

Funding

TAKE-IT TOO: Teen Adherence in KidnEy transplant Improving Tracking To Optimize OutcomesR01DK110737 · NIDDK · MCGILL UNIVERSITY HEALTH CTR RES INST · PI DE VITO DABBS, ANNETTE J, FOSTER, BETHANY JOY · 2016 to 2020
$2.8M
Increasing Equity in Transplant Evaluation and Living Donor Kidney TransplantationR01DK101715 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEW, MARY AMANDA · 2014 to 2018
$2.7M
NIDDK NIH HHS R01 DK101715NIDDK NIH HHS R01 DK110737
6 · The paper itself

Abstract

purpose of reviewNon-adherence to the medical regimen after kidney transplantation can contribute to poor clinical outcomes, and strategies to maximize adherence are sought by care providers and patients alike. We assessed recent evidence on prevalence, risk factors, and clinical outcomes associated with non-adherence to the medical regimen after kidney transplantation. We summarized recent clinical trials testing interventions to improve adherence and generated recommendations for future research and clinical practice. RECENT

findingsA large evidence base documents rates of non-adherence to each of the multiple components of the regimen, including medication-taking, lifestyle activities, clinical care requirements, and substance use restrictions. Some risk factors for non-adherence are well known but the full range of risk factors remains unclear. Non-adherence to immunosuppressants and to other components of the regimen increases morbidity and mortality risks. Recent interventions, including education and counseling; electronic health strategies; and medication dose modifications, show promise for reducing immunosuppressant non-adherence. However, most of these interventions would be difficult to deploy in everyday clinical practice. Systematic dissemination of efficacious interventions into clinical practice has not been undertaken. SUMMARY: Rates and risk factors for non-adherence to the medical regimen have been examined and there is evidence that non-adherence may be ameliorated by a range of interventions. Although gaps in the evidence base remain, it would be timely to devote greater efforts to dissemination of findings. Thus, efforts are needed to assist transplant programs in using existing evidence to better identify patients who are non-adherent and to design and implement strategies to reduce or prevent non-adherence.

Indexed as

Immunosuppressant non-adherenceKidney transplantationMedical non-adherenceNon-adherence interventionsRisk factorsSubstance use

Identifiers

PMID30416933
PMCPMC6224171
OpenAlexW2799812622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.