ReviewAmerican journal of cancer research2018
Optogenetics: the new molecular approach to control functions of neural cells in epilepsy, depression and tumors of the central nervous system.
Review in American journal of cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.Nature communications · 2026Article
- Monolithic multimodal neural probes for sustained stimulation and long-term neural recording.Science advances · 2025Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.bioRxiv : the preprint server for biology · 2025Article
- Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery.JOR spine · 2025Review
- Review
- Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy.Molecular neurobiology · 2024Article
- Tapered fibertrodes for optoelectrical neural interfacing in small brain volumes with reduced artefacts.Nature materials · 2022Article
- Orthogonalization of far-field detection in tapered optical fibers for depth-selective fiber photometry in brain tissue.APL photonics · 2022Article
- A Computational Protocol for Regulating Protein Binding Reactions with a Light-Sensitive Protein Dimer.Journal of molecular biology · 2020Article
- New era of optogenetics: from the central to peripheral nervous system.Critical reviews in biochemistry and molecular biology · 2020Review
- Impedance Measures and a Mounting Technique for Drosophila: Larval Movements, Heart Rate, Imaging, and Electrophysiology.Methods and protocols · 2020Article
- Reduced Information Transmission of Medial Prefrontal Cortex to Basolateral Amygdala Inhibits Exploratory Behavior in Depressed Rats.Frontiers in neuroscience · 2020Article
- Progress in Stem Cell Therapy for Spinal Cord Injury.Stem cells international · 2020Review
- The Effects of Chloride Flux onMethods and protocols · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The optogenetic tools have been described as valuable techniques to study neural activity through light stimulation, as well as potential neuromodulator approaches in the management of several central nervous system (CNS) diseases. Since the first bacteriorhodopsin protein described as a single-component light-activated regulator of transmembrane ion flow description, in 1980's, the focus has been on channel proteins for neurobiology; however, the advances in engineering techniques showed involvement changes in cellular biological behavior in several types of proteins involved in cell cytoskeleton regulation, motility and gene expression. Although the use of this technology has been published in many papers, a question still remains regarding real results and potential clinical applicability in CNS diseases, as well as the publications scarcity that systematically analyses the published results. Lastly, the aim of this review is to discuss the experimental results, molecular mechanisms and potential clinical applications of optogenetic tools in epilepsy and depression treatment, as well as its applicability in the treatment of CNS tumors.
Indexed as
Identifiers
30416844PMC6220144What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.