ArticleJournal of ophthalmology2018
Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma.
Article in Journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review.Physical and engineering sciences in medicine · 2024Pooled it
- Biomechanical changes and associated factors of preserved SMILE-derived corneal stromal lenticules.Eye (London, England) · 2026Article
- Preoperative Corneal Astigmatic Direction is Associated with Stromal Mechanical Anisotropy in SMILE-Derived Lenticules.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Microstructure and In-Plane Mechanical Property Comparison of Human and Porcine Cornea.Journal of biomechanical engineering · 2025Article
- Advances in 3D Bioprinting for Corneal Regeneration.Gels (Basel, Switzerland) · 2025Review
- Review
- [Anisotropy and viscoelasticity of different corneal regions in rabbit corneal ectasia model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Non-contact tonometry: predicting intraocular pressure using a material-corneal thickness-independent methodology.Frontiers in bioengineering and biotechnology · 2024Article
- Corneal Biomechanical Properties Demonstrate Anisotropy and Correlate With Axial Length in Myopic Eyes.Investigative ophthalmology & visual science · 2023Article
- Review
- Effectiveness of collagen cross-linking induced by two-photon absorption properties of a femtosecond laser inBiomedical optics express · 2022Article
- Measuring Human Corneal Stromal Biomechanical Properties Using Tensile Testing Combined With Optical Coherence Tomography.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the anisotropic characteristics of the normal human corneal stroma using fresh corneal tissue.
methodsSixty-four corneal specimens extracted from stromal lenticules were included in this study. The specimens were cut in the temporal-nasal (horizontal) or superior-inferior (vertical) direction. Strip specimens were subjected to uniaxial tensile testing. The tensile properties of the specimens were measured and compared in the two directions.
resultsThe low-strain tangent modulus was statistically significantly greater in the vertical direction than in the horizontal direction (1.32 ± 0.50 MPa vs 1.17 ± 0.43 MPa;
conclusionsThe biomechanical behavior in normal human corneal stroma tissue is slightly stiffer in the vertical direction than in the horizontal direction. This information may aid our understanding of the biomechanical properties of the cornea and related diseases.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.