ArticleJournal of thoracic disease2018
Spread through air spaces predicts a worse survival in patients with stage I adenocarcinomas >2 cm after radical lobectomy.
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Preoperative predictive factors and the prognostic impact of spread through air spaces in clinical stage IA lung adenocarcinoma.Surgery today · 2026Article
- Prognostic Value of STAS, Lymph Node Metastasis, and VPI in NSCLC ≤ 4 cm Treated with Lobectomy.Journal of clinical medicine · 2025Article
- Article
- The More Extensive the Spread through Air Spaces, the Worse the Prognosis Is: Semi-Quantitative Evaluation of Spread through Air Spaces in Pulmonary Adenocarcinomas.Pathobiology : journal of immunopathology, molecular and cellular biology · 2023Article
- Retrospective analysis of the prognostic implications of tumor spread through air spaces in lung adenocarcinoma patients treated with surgery.ESMO open · 2022Observational
- Clinicopathological Impact of the Spread through Air Space in Non-Small Cell Lung Cancer: A Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Assessment of the feasibility of frozen sections for the detection of spread through air spaces (STAS) in pulmonary adenocarcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Comprehensive analysis for clarifying transcriptomics landscapes of spread through air spaces in lung adenocarcinoma.Frontiers in genetics · 2022Article
- Correlation analysis between metabolic tumor burden measured by positron emission tomography/computed tomography and the 2015 World Health Organization classification of lung adenocarcinoma, with a risk prediction model of tumor spread through air spaces.Translational cancer research · 2020Article
- Comprehensive analysis of spread through air spaces in lung adenocarcinoma and squamous cell carcinoma using the 8th edition AJCC/UICC staging system.BMC cancer · 2020Article
- Significance of tumor spread through air spaces (STAS) in lung cancer from the pathologist perspective.Translational lung cancer research · 2020Review
- Spread Through Air Spaces (STAS) in Lung Cancer: A Multiple-Perspective and Update Review.Cancer management and research · 2020Review
- Spread Through Air Spaces (STAS) Is Prognostic in Atypical Carcinoid, Large Cell Neuroendocrine Carcinoma, and Small Cell Carcinoma of the Lung.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Article
- Erratum: Spread through air spaces predicts a worse survival in patients with stage I adenocarcinomas >2 cm after radical lobectomy.Journal of thoracic disease · 2019Article
- Advances In Research Of Spreading Through Air Spaces And The Effects On The Prognosis Of Lung Cancer.Cancer management and research · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the significance of spread through air spaces (STAS) in early lung adenocarcinomas after radical lobectomy and lymphadenectomy.
methodsA total of 242 patients with lung adenocarcinomas less than 4 cm (8th pStage I) were selected from the lung cancer patients surgically treated from January, 2009 to September, 2011. Pathological review focused on STAS as well as histological subtypes, blood vessel & neural invasion, pathological tumor size etc. Recurrence or disease-free survival (DFS) and overall survival (OS) were compared between patients as stratified by STAS and tumor size.
resultsSTAS was observed in 33.47% (81/242) patients, which was significantly correlated with histological predominant subtype (χ
conclusionsPresence of STAS was a significant worse predictor for pStage I patients with lung adenocarcinoma >2 cm who underwent radical lobectomy, while it is not significant in patients with tumor ≤2 cm. These findings may be helpful in assessing postoperative therapy stratified by tumor size and STAS status.
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Registered trials
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