Evidence map›Paper›PMID 30416677›Full record

ArticleOncotarget2018

Chronic heart failure is characterized by altered mitochondrial function and structure in circulating leucocytes.

Roberta Coluccia, Salvatore Raffa, Danilo Ranieri, Andrea Micaloni, Sabatino Valente, Gerardo Salerno, Cristina Scrofani, Marco Testa, Giovanna Gallo, Erika Pagannone and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Hypertension and Heart Failure: From Pathophysiology to Treatment.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Unlocking the Value of White Blood Cells for Heart Failure Diagnosis.Journal of cardiovascular translational research · 2021
    Review
  11. Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Roberta Coluccia *IRCCS Neuromed, Pozzilli, Isernia, Italy.
Salvatore Raffa *Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Danilo RanieriDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Andrea MicaloniDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Sabatino ValenteDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Gerardo SalernoDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Cristina ScrofaniDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Marco TestaCardiology Unit, Sant'Andrea University Hospital, Rome, Italy.
Giovanna GalloDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Erika PagannoneCardiology Unit, Sant'Andrea University Hospital, Rome, Italy.
Maria Rosaria TorrisiDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.
Massimo VolpeIRCCS Neuromed, Pozzilli, Isernia, Italy.
Speranza RubattuIRCCS Neuromed, Pozzilli, Isernia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is currently viewed as a key factor in the genesis and progression of Heart Failure (HF). The aim of this study was to characterize the mitochondrial changes linked to oxidative stress generation in circulating peripheral blood mononuclear cells isolated from chronic HF patients (HF_PBMCs) in order to highlight the involvement of mitochondrial dysfunction in the pathophysiology of HF. To assess the production of reactive oxygen species (ROS), mitochondrial function and ultrastructure and the mitophagic flux in circulating PBMCs we enrolled 15 patients with HF and a control group of ten healthy subjects. The HF_PBMCs showed a mitochondrial population consisting of damaged and less functional organelles responsible of higher superoxide anion production both at baseline and under

Indexed as

heart failuremitochondrial dysfunctionmitophagyoxidative stressPathologyperipheral blood mononuclear cells

Identifiers

PMID30416677
PMCPMC6205552

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.