Evidence map›Paper›PMID 30416658›Full record

ArticleAmerican journal of translational research2018

880 kHz ultrasound treatment for drug delivery to the vitreous humor.

Ricardo Lamy, Elliot Chan, On-Tat Lee, Audrey Phone, Vasant A Salgaonkar, Chris J Diederich, Jay M Stewart

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Ultrasound-targeted microbubble destruction-mediatedAnnals of translational medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ricardo LamyDepartment of Ophthalmology, University of California San Francisco, CA, USA.
Elliot ChanDepartment of Ophthalmology, University of California San Francisco, CA, USA.
On-Tat LeeDepartment of Ophthalmology, University of California San Francisco, CA, USA.
Audrey PhoneDepartment of Ophthalmology, University of California San Francisco, CA, USA.
Vasant A SalgaonkarDepartment of Radiation Oncology, University of California San Francisco, CA, USA.
Chris J DiederichDepartment of Radiation Oncology, University of California San Francisco, CA, USA.
Jay M StewartDepartment of Ophthalmology, University of California San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
Ultrasound-enhanced corneal drug deliveryR01EY024004 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEWART, JAY MICHAEL · 2017 to 2020
$1.6M
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY024004
6 · The paper itself

Abstract

Clinical management of many chronic ophthalmological disorders requires direct delivery of drugs into the vitreous. There is an important need to investigate novel needle-less alternatives to deliver drugs to the vitreous. The purpose of this study is to assess the effects of a needle-less system using ultrasound to enhance vitreal delivery of small molecules through the sclera in an

Indexed as

drug delivery systemsintravitrealscleraUltrasonicvitreous

Identifiers

PMID30416658
PMCPMC6220232
OpenAlexW3023763315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.