Evidence map›Paper›PMID 30416429›Full record

ArticleFrontiers in cellular neuroscience2018

Short-Term Plasticity at Olfactory Cortex to Granule Cell Synapses Requires Ca

Fu-Wen Zhou, Adam C Puche, Michael T Shipley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fu-Wen ZhouDepartment of Anatomy and Neurobiology, Program in Neurosciences, University of Maryland School of Medicine, Baltimore, MD, United States.
Adam C PucheDepartment of Anatomy and Neurobiology, Program in Neurosciences, University of Maryland School of Medicine, Baltimore, MD, United States.
Michael T ShipleyDepartment of Anatomy and Neurobiology, Program in Neurosciences, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · US

Funding

Olfactory Glomeruli: Cellular and Network MechanismsR01DC005676 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI SHIPLEY, MICHAEL THOMAS · 2002 to 2017
$5.8M
Supplement to Basal Forebrain Modulation of Olfactory Bulb FunctionR01DC010915 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI PUCHE, ADAM C · 2011 to 2022
$5.7M
NIDCD NIH HHS R01 DC005676NIDCD NIH HHS R01 DC010915
6 · The paper itself

Abstract

Output projections of the olfactory bulb (OB) to the olfactory cortex (OCX) and reciprocal feedback projections from OCX provide rapid regulation of OB circuit dynamics and odor processing. Short-term synaptic plasticity (STP), a feature of many synaptic connections in the brain, can modulate the strength of feedback based on preceding network activity. We used light-gated cation channel channelrhodopsin-2 (ChR2) to investigate plasticity of excitatory synaptic currents (EPSCs) evoked at the OCX to granule cell (GC) synapse in the OB. Selective activation of OCX glutamatergic axons/terminals in OB generates strong, frequency-dependent STP in GCs. This plasticity was critically dependent on activation of Ca

Indexed as

CaV2.1 channelsfeedback projectionslight-gated cation channel channelrhodopsin-2olfactory bulbolfactory cortexshort-term synaptic plasticity

Identifiers

PMID30416429
PMCPMC6212651
OpenAlexW2898260326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.