ArticleJournal of Korean medical science2018
Antidepressant Prescription Patterns in Bipolar Disorder: a Nationwide, Register-based Study in Korea.
Article in Journal of Korean medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Analysis of the prescription pattern of psychotropics in an outpatient department of a general hospital psychiatry unit.Medical journal, Armed Forces India · 2022Article
- Has Bipolar Disorder become a predominantly female gender related condition? Analysis of recently published large sample studies.International journal of bipolar disorders · 2021Article
- Real-world clinical features of and antidepressant prescribing patterns for outpatients with bipolar disorder.BMC psychiatry · 2020Article
- The effects of vagus nerve stimulation on the course and outcomes of patients with bipolar disorder in a treatment-resistant depressive episode: a 5-year prospective registry.International journal of bipolar disorders · 2020Article
- Comparison of serum protein profiles between major depressive disorder and bipolar disorder.BMC psychiatry · 2020Article
- Complex Combination Pharmacotherapy for Bipolar Disorder: Knowing When Less Is More or More Is Better.Focus (American Psychiatric Publishing) · 2019Review
- Examining Patterns of Polypharmacy in Bipolar Disorder: Findings from the REAP-BD, Korea.Psychiatry investigation · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of antidepressants (ADs) in bipolar disorder is long-standing controversial issue in psychiatry. Many clinicians have used ADs as a treatment for bipolar depression, and the selection of therapeutic agents is very diverse and inconsistent. This study aimed to examine recent AD prescription patterns for patients with bipolar disorder in Korea, using the nationwide, population-based data.
methodsThis study utilized the Korean nationwide, whole population-based registry data of the year 2010, 2011, and 2013. All prescription data of the ADs, antipsychotics, and mood stabilizers of the sampled patients diagnosed with bipolar disorder (n = 2,022 [in 2010]; 2,038 [in 2011]; 2,626 [in 2013]) were analyzed for each year.
resultsAnnual prescription rate of ADs was 27.3%-33.6% in bipolar disorder, which was gradually increasing over the 3-year period. The combination pattern of ADs and antipsychotic drugs tended to increase over 3 years. The proportion of females and the prevalence of comorbid anxiety disorder were significantly higher in AD user group in all three years. Among individual ADs, escitalopram was prescribed most frequently, and fluoxetine and bupropion were prescribed to the next many patients. The mean duration of bipolar depressive episodes was 135.90-152.53 days, of which ADs were prescribed for 115.60-121.98 days.
conclusionOur results show prescription rate of ADs in bipolar disorder was maintained at substantial level and increased in recent 3 years. More empirical data and evidence are needed to establish practical treatment consensuses.
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