Evidence map›Paper›PMID 30416405›Full record

ArticleInternational journal of peptide research and therapeutics2018

Apoptotic Effect of Melittin Purified from Iranian Honey Bee Venom on Human Cervical Cancer HeLa Cell Line.

Hannaneh Zarrinnahad, Amir Mahmoodzadeh, Monireh Parviz Hamidi, Mehdi Mahdavi, Ali Moradi, Kamran Pooshang Bagheri, Delavar Shahbazzadeh

Open access · hybridAbstract read
In one paragraph

Article in International journal of peptide research and therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hannaneh Zarrinnahad1Biotechnology Research Center, Venom and Biotherapeutic Molecules Lab., Pasteur Institute of Iran, Tehran, Iran.
Amir Mahmoodzadeh2Biochemistry Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Monireh Parviz Hamidi1Biotechnology Research Center, Venom and Biotherapeutic Molecules Lab., Pasteur Institute of Iran, Tehran, Iran.
Mehdi Mahdavi3Immunology Department, Pasteur Institute of Iran, Tehran, Iran.
Ali Moradi4International Campus of Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Kamran Pooshang Bagheri1Biotechnology Research Center, Venom and Biotherapeutic Molecules Lab., Pasteur Institute of Iran, Tehran, Iran.
Delavar Shahbazzadeh1Biotechnology Research Center, Venom and Biotherapeutic Molecules Lab., Pasteur Institute of Iran, Tehran, Iran.
Pasteur Institute of Iran · IRBiotechnology Research Center · IRShahid Sadoughi University of Medical Sciences and Health Services · IRShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melittin, an amphipathic 26-residue peptide, is the main component of honey bee venom. Studies have been demonstrated that melittin has an inhibitory effect on proliferation of cancer cells. However, the precise mechanism of action is not completely understood. In the present study we have shown that purified melittin from Iranian honey bee venom shows anti-cancer effects on human cervical cancer cell line through induction of apoptosis. The venom was collected from Iranian honey bee (

Indexed as

Apis Mellifera medaApoptosisCervical cancerHeLa cell lineMelittin

Identifiers

PMID30416405
PMCPMC6208649
OpenAlexW2767682157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.