Evidence map›Paper›PMID 30416214›Full record

ArticleTetrahedron2018

Syntheses of PDE3A inhibitor ORG9935 and determination of the absolute stereochemistries of its enantiomers by X-ray crystallography.

Sudhakar Jakkaraj, Victor G Young, Gunda I Georg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sudhakar JakkarajDepartment of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, United States.
Victor G YoungLeClair-Dow Chemical Instrumentation Facility, X-Ray Crystallographic Laboratory, Department of Chemistry, 207 Pleasant St. SE, Minneapolis, MN 55455.
Gunda I GeorgDepartment of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, United States.
University of Minnesota · USCargill (United States) · US

Funding

Nonhuman Primate Contraceptive CoreU54HD055744 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI STOUFFER, RICHARD L · 2007 to 2016
$13.8M
Drug Discovery & Synthesis of Contraceptive AgentsU01HD076542 · NICHD · UNIVERSITY OF MINNESOTA · PI GEORG, GUNDA I. · 2012 to 2016
$5.0M
NICHD NIH HHS HHSN275201300017CNICHD NIH HHS U01 HD076542NICHD NIH HHS U54 HD055744
6 · The paper itself

Abstract

Two synthetic methods were developed for the synthesis of PDE3A inhibitor ORG9935. The first one proceeds in six steps and 34% overall yield and the second one in five steps and an overall yield of 69% starting from commercially available starting material 5,6-dimethoxybenzo[

Indexed as

enantiomer separationfemale contraceptionORG9935PDE3A inhibitorstructure determinationSynthesis

Identifiers

PMID30416214
PMCPMC6223663
OpenAlexW2802258655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.