ArticleMolecular cell2018
An Insulin-Responsive Sensor in the SIRT1 Disordered Region Binds DBC1 and PACS-2 to Control Enzyme Activity.
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Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1.Biochemistry · 2026Article
- SIRT1 Exon 2-Encoded IDR Gates CREB-Dependent Transcriptional Timing During Fasting.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- PACS2 at Mitochondria-Associated Membranes: A Central Regulator of Cardiovascular and Metabolic Diseases.Journal of cellular and molecular medicine · 2026Review
- Factors Determining Sirtuin-1 Target Engagement.Advanced biology · 2026Review
- Phosphofurin Acidic Cluster Sorting Protein 2 Alleviates Kidney Fibrosis by Inhibiting Tubular Epithelial Cell G2/M Arrest through Cyclin-Dependent Kinase-Like 1.Journal of the American Society of Nephrology : JASN · 2026Article
- The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1.bioRxiv : the preprint server for biology · 2026Article
- PACS1 syndrome mutation disrupts dynein-mediated cargo transport via HDAC6 and BICD2.Communications biology · 2026Article
- Linking SIRT1 Variants to Metabolic and Cardiovascular Phenotypes: Insights from Population Genetics and In Silico Structural Analysis.Cell biochemistry and biophysics · 2026Review
- PACS2/PKCα/NOX4 pathway damaged the renal vascular endothelial barrier by promoting ROS production in diabetic nephropathy mice.Molecular and cellular biochemistry · 2025Article
- Article
- SIRT1-Mediated Mitochondrial Homeostasis in Cardiac Aging: Molecular Mechanisms and Therapeutic Implications.Aging and disease · 2025Review
- Understanding PACS2 syndrome's pathomechanism by studying E209K and E211K mutations.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Unraveling Diabetic Kidney Disease: The Roles of Mitochondrial Dysfunction and Immunometabolism.Kidney international reports · 2024Review
- Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification.Protein science : a publication of the Protein Society · 2024Article
- MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism.International journal of biological sciences · 2024Article
- Intrinsically disordered regions are poised to act as sensors of cellular chemistry.Trends in biochemical sciences · 2023Review
- Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy.Nature communications · 2023Article
- Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy.Current drug targets · 2023Article
- The differing effects of a dual acting regulator on SIRT1.Frontiers in molecular biosciences · 2023Article
- O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Troy C KrzysiakDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Laurel ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
You-Jin ChoiDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Sylvain AuclairDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Yiqi QianDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Shan LuanDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Stephanie M KrasnowDepartment of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA.
Laura L ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Leonardus M I KoharudinDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Panayiotis V BenosDepartment of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Daniel L MarksDepartment of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA.
Angela M GronenbornDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: amg100@pitt.edu.
Gary ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: thomasg@pitt.edu.
University of Pittsburgh · USOregon Health & Science University · USUPMC Hillman Cancer Center · US
Funding
Hypothalamic Mechanisms in CachexiaR01DK070333 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MARKS, DANIEL L. · 2004 to 2013
$2.6MAllosteric regulation of SIRT1 by a PACS-2 and DBC1 regulatory hubR01DK114855 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRONENBORN, ANGELA M., THOMAS, GARY · 2017 to 2020
$2.4MSystems Level Causal Discovery in Heterogeneous TOPMed DataU01HL137159 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, SCIURBA, FRANK · 2017 to 2019
$1.8MINTEGRATIVE GRAPHICAL MODELS FOR LARGE MULTI-MODAL BIOMEDICAL DATAR01LM012087 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, GLYMOUR, CLARK · 2015 to 2018
$1.3MRegulation of PPAR alpha by PACS-2 in response to nutrient stressR01DK112844 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMAS, GARY · 2017 to 2019
$1.2MNHLBI NIH HHS U01 HL137159NIDDK NIH HHS R01 DK070333NIDDK NIH HHS R01 DK112844NIDDK NIH HHS R01 DK114855NLM NIH HHS R01 LM012087
Abstract
Current models of SIRT1 enzymatic regulation primarily consider the effects of fluctuating levels of its co-substrate NAD
Indexed as
Adaptor Proteins, Signal TransducingAllosteric RegulationAnimalsBinding SitesDiet, High-FatDisease Models, AnimalGene Expression RegulationHCT116 CellsHepatocytesHeterocyclic Compounds, 4 or More RingsHumansInsulinInsulin ResistanceMaleMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Signal TransducingCCAR2 protein, humanHeterocyclic Compounds, 4 or More RingsInsulinKIAA1967 protein, mousePACS2 protein, humanPacs2 protein, mouseSIRT1 protein, humanSirt1 protein, mouseSirtuin 1SRT1720Vesicular Transport Proteins3-helix bundleAKTdiet-induced obesityFGF21liverNMR spectroscopynuclear magnetic resonance spectroscopyPACS2PGC-1alphaPPARalphasmall molecule sirtuin-activating compoundsSTACs
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