Evidence map›Paper›PMID 30415925›Full record

ArticleCell metabolism2019

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Jakob G Knudsen, Alexander Hamilton, Reshma Ramracheya, Andrei I Tarasov, Melissa Brereton, Elizabeth Haythorne, Margarita V Chibalina, Peter Spégel, Hindrik Mulder, Quan Zhang and 3 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05616273 (Stimulated Glucagon as a Biomarker of Hypoglycemic Risk in Type 1 Diabetes), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05616273 completednot on this mapstarted 2023, after this paper: background citation

Stimulated Glucagon as a Biomarker of Hypoglycemic Risk in Type 1 Diabetes

TypeobservationalSponsorUniversity of ExeterRan2023 to 2025Enrolled62ConditionsType 1 Diabetes, HypoglycemiaArmsMixed Meal Tolerance Test (MMTT), Arginine Stimulation Test (AST), Home Finger Prick Sample
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  13. Metabolic regulation of glucagon secretion.The Journal of endocrinology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jakob G KnudsenOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
Alexander HamiltonOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
Reshma RamracheyaOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
Andrei I TarasovOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
Melissa BreretonDepartment of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK.
Elizabeth HaythorneDepartment of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK.
Margarita V ChibalinaOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
Peter SpégelCentre for Analysis and Synthesis, Lund University Diabetes Centre, Department of Chemistry, Naturvetarvägen 14, Lund 221 00, Sweden.
Hindrik MulderUnit of Molecular Metabolism, Lund University Diabetes Centre, Department of Clinical Research in Malmö, Jan Waldenströms Gata 35, Malmö 205 02, Sweden.
Quan ZhangOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
Frances M AshcroftDepartment of Physiology, Anatomy & Genetics, Parks Road, Oxford OX1 3PT, UK.
Julie AdamOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Nuffield Department of Clinical Medicine, University of Oxford, NDM Research Building, Oxford OX3 7FZ, UK. Electronic address: julie.adam@ndm.ox.ac.uk.
Patrik RorsmanOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Metabolic Research, Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Göteborg, Box 433, Göteborg 405 30, Sweden. Electronic address: patrik.rorsman@drl.ox.ac.uk.
Oxford Centre for Diabetes, Endocrinology and Metabolism · GBUniversity of Oxford · GBLund University · SE

Funding

Medical Research Council G0801995Medical Research Council MR/T002107/1Wellcome Trust 089795Wellcome Trust 095531Wellcome Trust 095531/Z/11/ZWellcome Trust 884655
6 · The paper itself

Abstract

Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and too little at low glucose). The glucagon secretion defects are corrected by low concentrations of tolbutamide and prevented by the sodium-glucose transport (SGLT) inhibitor phlorizin. These data link hyperglycemia, intracellular Na

Indexed as

Adenosine TriphosphateAnimalsCell LineDiabetes Mellitus, Type 2GlucagonGlucagon-Secreting CellsHumansHyperglycemiaInsulinInsulin-Secreting CellsMaleMiceMice, Inbred C57BLPotassium ChannelsRatsRats, WistarAdenosine TriphosphateGlucagonInsulinPotassium ChannelsSodiumdiabetesFh1glucagonsodium-glucose co-transportsuccination

Identifiers

PMID30415925
PMCPMC6370947
OpenAlexW2899548656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.