ArticleCell2018
Reconstructing the Deep Population History of Central and South America.
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Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 2 of them syntheses that pooled it.
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137citing papers in PubMed, 2 pooled it
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Who cites it
137 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machado-Joseph disease in Brazil and other South American countries: A systematic Review and Meta-analysis of Prevalence, CAG Repeat Lengths, Age At Onset, and Ancestry.Cerebellum (London, England) · 2025Pooled it
- Spatiotemporal fluctuations of population structure in the Americas revealed by a meta-analysis of the first decade of archaeogenomes.American journal of biological anthropology · 2023Pooled it
- Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.PloS one · 2021Trial
- Ancient DNA as a temporal lens: reconstructing evolution, migration, and disease dynamics.Journal, genetic engineering & biotechnology · 2026Review
- Hemisphere-wide evidence of Early Paleoindian megaherbivore specialization.Science advances · 2026Article
- Ancient DNA reveals a family ossuary and long-distance migration on the Pacific coast before the Inca Empire.Nature communications · 2026Article
- First Lithic Age Caribbean genomes document pre-Ceramic genetic continuity and affinities to Central America and northern South America.bioRxiv : the preprint server for biology · 2026Article
- Article
- Demographic History of Indigenous Populations in Mexico Explored Through Whole Mitogenome Analysis.Genome biology and evolution · 2026Article
- Article
- Genomic roots of Indigenous Americans uncovered.Nature · 2026Article
- An ancient genome of Streptococcus pyogenes from a pre-Columbian Bolivian mummy.Nature communications · 2026Article
- Subsistence transition preceded population turnover in the eastern Colombian Andes.bioRxiv : the preprint server for biology · 2026Article
- Global patterns of natural selection inferred using ancient DNA.bioRxiv : the preprint server for biology · 2026Article
- Continuity and discontinuity in Native American populations: Insights from ancient and modern mitochondrial DNA.Genetics and molecular biology · 2026Article
- Article
- Mitochondrial genomes of Middle Pleistocene horses from the open-air site complex of Schöningen.Nature ecology & evolution · 2025Article
- Recommendations for responsible use of population descriptors in polygenic risk score development.Nature genetics · 2025Review
- Toward a Biocultural Synthesis of the Peopling of the Americas: Introduction to the Special Issue.American journal of biological anthropology · 2025Article
- Human population history on the North Coast of peru from Y chromosomes and mitogenomes.Scientific reports · 2025Article
77 more citing papers are in PubMed but not listed here.
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Authors and funding
72 authors.
Cosimo PosthDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany; Institute for Archaeological Sciences, Archaeo- and Palaeogenetics, University of Tübingen, Tübingen 72070, Germany. Electronic address: posth@shh.mpg.de.
Nathan NakatsukaDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Boston, MA 02115, USA. Electronic address: nathan_nakatsuka@hms.harvard.edu.
Iosif LazaridisDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Pontus SkoglundDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Francis Crick Institute, London NW1 1AT, UK.
Swapan MallickDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Thiseas C LamnidisDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
Nadin RohlandDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Kathrin NägeleDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
Nicole AdamskiDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Emilie BertoliniDipartimento di Biologia e Biotecnologie, Università di Pavia, Pavia 27100, Italy.
Nasreen BroomandkhoshbachtDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Alan CooperAustralian Centre for Ancient DNA, School of Biological Sciences and The Environment Institute, Adelaide University, Adelaide, SA 5005, Australia.
Brendan J CulletonDepartment of Anthropology, The Pennsylvania State University, University Park, PA 16802, USA; Institutes of Energy and the Environment, The Pennsylvania State University, University Park, PA 16802, USA.
Tiago FerrazDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany; Departamento de Genética e Biologia Evolutiva, Universidade de São Paulo, São Paulo 05508-090, Brazil.
Matthew FerryDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Anja FurtwänglerInstitute for Archaeological Sciences, Archaeo- and Palaeogenetics, University of Tübingen, Tübingen 72070, Germany.
Wolfgang HaakDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
Kelly HarkinsUCSC Paleogenomics, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Thomas K HarperDepartment of Anthropology, The Pennsylvania State University, University Park, PA 16802, USA.
Tábita HünemeierDepartamento de Genética e Biologia Evolutiva, Universidade de São Paulo, São Paulo 05508-090, Brazil.
Ann Marie LawsonDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Bastien LlamasAustralian Centre for Ancient DNA, School of Biological Sciences and The Environment Institute, Adelaide University, Adelaide, SA 5005, Australia.
Megan MichelDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Elizabeth NelsonDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany; Institute for Archaeological Sciences, Archaeo- and Palaeogenetics, University of Tübingen, Tübingen 72070, Germany.
Jonas OppenheimerDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Nick PattersonBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Stephan SchiffelsDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
Jakob SedigDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Kristin StewardsonDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Sahra TalamoDepartment of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
Chuan-Chao WangDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany; Department of Anthropology and Ethnology, Xiamen University, Xiamen 361005, China.
Jean-Jacques HublinDepartment of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
Mark HubbeDepartment of Anthropology, The Ohio State University, Columbus, OH 43210, USA; Instituto de Arqueología y Antropología, Universidad Católica del Norte, San Pedro de Atacama, Región de Antofagasta, Antofagasta CP 1410000, Chile.
Katerina HarvatiInstitute for Archaeological Sciences, Palaeoanthropology and Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tuebingen, Tübingen 72070, Germany; DFG Center for Advanced Studies, "Words, Bones, Genes, Tools," University of Tübingen, Tübingen 72070, Germany.
Amalia Nuevo DelaunayCentro de Investigación en Ecosistemas de la Patagonia, Coyhaique 5951601, Chile.
Judith BeierInstitute for Archaeological Sciences, Palaeoanthropology and Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tuebingen, Tübingen 72070, Germany.
Michael FranckenInstitute for Archaeological Sciences, Palaeoanthropology and Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tuebingen, Tübingen 72070, Germany.
Peter KaulickePontifical Catholic University of Peru, San Miguel, Lima 32, Peru.
Hugo Reyes-CentenoInstitute for Archaeological Sciences, Palaeoanthropology and Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tuebingen, Tübingen 72070, Germany; DFG Center for Advanced Studies, "Words, Bones, Genes, Tools," University of Tübingen, Tübingen 72070, Germany.
Kurt RademakerDepartment of Anthropology, Michigan State University, East Lansing, MI 48824, USA.
Willa R TraskCentral Identification Laboratory, Defense POW/MIA Accounting Agency, Department of Defense, Joint Base Pearl Harbor-Hickam, HI 96853, USA.
Mark RobinsonDepartment of Archaeology, Exeter University, Exeter EX4 4QJ, UK.
Said M GutierrezYa'axché Conservation Trust, Punta Gorda Town, Belize.
Keith M PruferDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131, USA; Center for Stable Isotopes, University of New Mexico, Albuquerque, NM 87131, USA.
Domingo C Salazar-GarcíaDepartment of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany; Grupo de Investigación en Prehistoria IT-622-13 (UPV-EHU), IKERBASQUE-Basque Foundation for Science, Vitoria, Spain.
Eliane N ChimMuseu de Arqueologia e Etnologia, Universidade de São Paulo, São Paulo 05508-070, Brazil.
Lisiane Müller Plumm GomesDepartamento de Genética e Biologia Evolutiva, Universidade de São Paulo, São Paulo 05508-090, Brazil.
Marcony L AlvesMuseu de Arqueologia e Etnologia, Universidade de São Paulo, São Paulo 05508-070, Brazil.
Andersen LiryoMuseu Nacional da Universidade Federal do Rio de Janeiro, Rio de Janeiro 20940-040, Brazil.
Mariana InglezDepartamento de Genética e Biologia Evolutiva, Universidade de São Paulo, São Paulo 05508-090, Brazil.
Rodrigo E OliveiraDepartamento de Genética e Biologia Evolutiva, Universidade de São Paulo, São Paulo 05508-090, Brazil; Departamento de Estomatologia, Faculdade de Odontologia, Universidade de São Paulo, São Paulo 05508-000, Brazil.
Danilo V BernardoLaboratório de Estudos em Antropologia Biológica, Bioarqueologia e Evolução Humana, Instituto de Ciências Humanas e da Informação, Universidade Federal do Rio Grande, Rio Grande do Sul 96203-900, Brazil.
Alberto BarioniFaculdade de Filosofia Ciencias e Letras, Universidade de São Paulo, São Paulo 05508-080, Brazil.
Veronica WesolowskiMuseu de Arqueologia e Etnologia, Universidade de São Paulo, São Paulo 05508-070, Brazil.
Nahuel A ScheiflerINCUAPA-CONICET, Facultad de Ciencias Sociales, Universidad Nacional del Centro de la Provincia de Buenos Aires, Olavarría 7400, Argentina.
Mario A RiveraComité Chileno del Consejo Internacional de Monumentos y Sitios, Santiago 8320000, Chile; Field Museum of Natural History, Chicago, IL 60605, USA; Universidad de Magallanes, Punta Arenas 6200000, Chile.
Claudia R PlensEscola De Filosofia, Letras E Ciências Humanas, Universidade Federal de São Paulo, São Paulo 07252-312, Brazil.
Pablo G MessineoINCUAPA-CONICET, Facultad de Ciencias Sociales, Universidad Nacional del Centro de la Provincia de Buenos Aires, Olavarría 7400, Argentina.
Levy FigutiMuseu de Arqueologia e Etnologia, Universidade de São Paulo, São Paulo 05508-070, Brazil.
Daniel CorachServicio de Huellas Digitales Genéticas, School of Pharmacy and Biochemistry, Universidad de Buenos Aires y CONICET, Ciudad Autonoma de Buenos Aires, Junin 954, Argentina.
Clara ScabuzzoCONICET-División Arqueología, Facultad de Ciencias Naturales y Museo, La Plata 1900, Argentina.
Sabine EggersDepartamento de Genética e Biologia Evolutiva, Universidade de São Paulo, São Paulo 05508-090, Brazil; Naturhistorisches Museum Wien, Vienna 1010, Austria.
Paulo DeBlasisMuseu de Arqueologia e Etnologia, Universidade de São Paulo, São Paulo 05508-070, Brazil.
Markus ReindelGerman Archaeological Institute, Commission for Archaeology of Non-European Cultures, Bonn 53173, Germany.
César MéndezCentro de Investigación en Ecosistemas de la Patagonia, Coyhaique 5951601, Chile.
Gustavo PolitisINCUAPA-CONICET, Facultad de Ciencias Sociales, Universidad Nacional del Centro de la Provincia de Buenos Aires, Olavarría 7400, Argentina.
Elsa Tomasto-CagigaoPontifical Catholic University of Peru, San Miguel, Lima 32, Peru.
Douglas J KennettDepartment of Anthropology, The Pennsylvania State University, University Park, PA 16802, USA; Institutes of Energy and the Environment, The Pennsylvania State University, University Park, PA 16802, USA.
André StraussDepartamento de Genética e Biologia Evolutiva, Universidade de São Paulo, São Paulo 05508-090, Brazil; Institute for Archaeological Sciences, Palaeoanthropology and Senckenberg Centre for Human Evolution and Palaeoenvironment, University of Tuebingen, Tübingen 72070, Germany; Museu de Arqueologia e Etnologia, Universidade de São Paulo, São Paulo 05508-070, Brazil; Centro de Arqueologia Annette Laming Emperaire, Miguel A Salomão, Lagoa Santa, MG 33400-000, Brazil.
Lars Fehren-SchmitzUCSC Paleogenomics, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; UCSC Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Johannes KrauseDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena 07745, Germany; Institute for Archaeological Sciences, Archaeo- and Palaeogenetics, University of Tübingen, Tübingen 72070, Germany.
David ReichDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: reich@genetics.med.harvard.edu.
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MMethods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3MPopulation mixture in evolutionary and medical geneticsR01GM100233 · NIGMS · HARVARD MEDICAL SCHOOL · PI PATTERSON, NICK J, REICH, DAVID E · 2012 to 2019
$2.7MHoward Hughes Medical InstituteMedical Research Council FC001595NHGRI NIH HHS R01 HG006399NIGMS NIH HHS R01 GM100233NIGMS NIH HHS T32 GM007753Wellcome Trust FC001595
Abstract
We report genome-wide ancient DNA from 49 individuals forming four parallel time transects in Belize, Brazil, the Central Andes, and the Southern Cone, each dating to at least ∼9,000 years ago. The common ancestral population radiated rapidly from just one of the two early branches that contributed to Native Americans today. We document two previously unappreciated streams of gene flow between North and South America. One affected the Central Andes by ∼4,200 years ago, while the other explains an affinity between the oldest North American genome associated with the Clovis culture and the oldest Central and South Americans from Chile, Brazil, and Belize. However, this was not the primary source for later South Americans, as the other ancient individuals derive from lineages without specific affinity to the Clovis-associated genome, suggesting a population replacement that began at least 9,000 years ago and was followed by substantial population continuity in multiple regions.
Indexed as
Genome, HumanCentral AmericaDNA, AncientDNA, MitochondrialGene FlowGenetics, PopulationHistory, AncientHumansModels, TheoreticalSouth AmericaDNA, AncientDNA, MitochondrialanthropologyarchaeologyCentral Americapopulation geneticsSouth America
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