ArticleJournal of biomedical optics2018
Correcting Cherenkov light attenuation in tissue using spatial frequency domain imaging for quantitative surface dosimetry during whole breast radiation therapy.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Real-time motion tracking of a gold implant in water by Cherenkov lights.Journal of applied clinical medical physics · 2026Article
- Monte Carlo modeling and phantom studies show Cherenkov emission per unit dose during total skin electron therapy is a function of tissue optical properties.Medical physics · 2026Article
- Cherenkov Imaged Bio-Morphological Features Verify Patient Positioning With Deformable Tissue Translocation in Breast Radiation Therapy.Advances in radiation oncology · 2025Article
- Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy.Frontiers in medicine · 2025Review
- Assessment of scintillation and Cherenkov imaging as beam shape verification method in CyberKnife® radiotherapy.Journal of applied clinical medical physics · 2024Article
- Cherenkov imaging combined with scintillation dosimetry provides real-time positional and dose monitoring for radiotherapy patients with cardiac implanted electronic devices.Physics and imaging in radiation oncology · 2024Article
- Review of Cherenkov imaging technology advances in radiotherapy: single-photon-level imaging in high ambient light and radiation backgrounds.Biophotonics discovery · 2024Review
- Imaging and characterization of optical emission fromPhysics in medicine and biology · 2024Article
- Characterization of Cherenkov imaging parameters and positional constraints on an O-ring linear accelerator.Physics in medicine and biology · 2023Article
- Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content.Journal of biomedical optics · 2023Article
- Remote dose imaging from Cherenkov light using spatially resolved CT calibration in breast radiotherapy.Medical physics · 2022Article
- Image guidance for FLASH radiotherapy.Medical physics · 2022Article
- Wavelength and frequency optimization in spatial frequency domain imaging for two-layer tissue.Biomedical optics express · 2022Article
- Color Cherenkov imaging of clinical radiation therapy.Light, science & applications · 2021Article
- Optical emission-based phantom to verify coincidence of radiotherapy and imaging isocenters on an MR-linac.Journal of applied clinical medical physics · 2021Article
- Estimation of diffuse Cherenkov optical emission from external beam radiation build-up in tissue.Journal of biomedical optics · 2021Article
- Spatial and temporal dosimetry of individual electron FLASH beam pulses using radioluminescence imaging.Physics in medicine and biology · 2021Article
- Initial Clinical Experience of Cherenkov Imaging in External Beam Radiation Therapy Identifies Opportunities to Improve Treatment Delivery.International journal of radiation oncology, biology, physics · 2021Article
- Detective quantum efficiency of intensified CMOS cameras for Cherenkov imaging in radiotherapy.Physics in medicine and biology · 2020Article
- Theoretical lateral and axial sensitivity limits and choices of molecular reporters for Cherenkov-excited luminescence in tissue during x-ray beam scanning.Journal of biomedical optics · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imaging Cherenkov emission during radiotherapy permits real-time visualization of external beam delivery on superficial tissue. This signal is linear with absorbed dose in homogeneous media, indicating potential for quantitative dosimetry. In humans, the inherent heterogeneity of tissue optical properties (primarily from blood and skin pigment) distorts the linearity between detected Cherenkov signal and absorbed dose. We examine the potential to correct for superficial vasculature using spatial frequency domain imaging (SFDI) to map tissue optical properties for large fields of view. In phantoms, applying intensity corrections to simulate blood vessels improves Cherenkov image (CI) negative contrast by 24% for a vessel 1.9-mm-in diameter. In human trials, SFDI and CI are acquired for women undergoing whole breast radiotherapy. Applied corrections reduce heterogeneity due to vasculature within the sampling limits of the SFDI from a 22% difference as compared to the treatment plan, down to 6% in one region and from 14% down to 4% in another region. The optimal use for this combined imaging system approach is to correct for small heterogeneities such as superficial blood vessels or for interpatient variations in blood/melanin content such that the corrected CI more closely represents the surface dose delivered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.