Evidence map›Paper›PMID 30415432›Full record

Trial reportAIDS and behavior2019

Understanding the Time Needed to Link to Care and Start ART in Seven HPTN 071 (PopART) Study Communities in Zambia and South Africa.

Janet Seeley, Virginia Bond, Blia Yang, Sian Floyd, David MacLeod, Lario Viljoen, Mwelwa Phiri, Melvin Simuyaba, Graeme Hoddinott, Kwame Shanaube and 12 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. CD4+ T-Cell Count at Antiretroviral Therapy Initiation in the "Treat-All" Era in Rural South Africa: An Interrupted Time Series Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Janet SeeleyLondon School of Hygiene and Tropical Medicine, London, UK. janet.seeley@lshtm.ac.uk.ORCID http://orcid.org/0000-0002-0583-5272
Virginia BondLondon School of Hygiene and Tropical Medicine, London, UK.
Blia YangDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, K-Floor, Clinical Building, Tygerberg Medical Campus, Francie van Zyl Drive, Tygerberg, 7505, South Africa.
Sian FloydLondon School of Hygiene and Tropical Medicine, London, UK.
David MacLeodLondon School of Hygiene and Tropical Medicine, London, UK.
Lario ViljoenDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, K-Floor, Clinical Building, Tygerberg Medical Campus, Francie van Zyl Drive, Tygerberg, 7505, South Africa.
Mwelwa PhiriZambart, School of Medicine, University of Zambia, Ridgeway Campus, Lusaka, Zambia.
Melvin SimuyabaZambart, School of Medicine, University of Zambia, Ridgeway Campus, Lusaka, Zambia.
Graeme HoddinottDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, K-Floor, Clinical Building, Tygerberg Medical Campus, Francie van Zyl Drive, Tygerberg, 7505, South Africa.
Kwame ShanaubeZambart, School of Medicine, University of Zambia, Ridgeway Campus, Lusaka, Zambia.
Chiti BwalyaZambart, School of Medicine, University of Zambia, Ridgeway Campus, Lusaka, Zambia.
Laing de VilliersDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, K-Floor, Clinical Building, Tygerberg Medical Campus, Francie van Zyl Drive, Tygerberg, 7505, South Africa.
Karen JenningsCity of Cape Town Health Directorate, Cape Town, South Africa.
Margaret MwanzaZambia Prevention Care and Treatment partnership (ZPCT), Lusaka, Zambia.
Ab SchaapZambart, School of Medicine, University of Zambia, Ridgeway Campus, Lusaka, Zambia.
Rory DunbarDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, K-Floor, Clinical Building, Tygerberg Medical Campus, Francie van Zyl Drive, Tygerberg, 7505, South Africa.
Kalpana SabapathyLondon School of Hygiene and Tropical Medicine, London, UK.
Helen AylesLondon School of Hygiene and Tropical Medicine, London, UK.
Peter BockDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, K-Floor, Clinical Building, Tygerberg Medical Campus, Francie van Zyl Drive, Tygerberg, 7505, South Africa.
Richard HayesLondon School of Hygiene and Tropical Medicine, London, UK.
Sarah FidlerDepartment of Medicine, Imperial College, London, UK.
HPTN 071 (PopART) study team

Funding

SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
Leadership for HIV/AIDS Clinical Trials Networks; HIV Prevention Trials NetworkU01AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DONNELL, DEBORAH J · 2006 to 2010
$28.8M
Medical Research Council MR/K012126/1NIAID NIH HHS U01 AI068617NIAID NIH HHS UM1 AI068617
6 · The paper itself

Abstract

To achieve UNAIDS 90:90:90 targets at population-level, knowledge of HIV status must be followed by timely linkage to care, initiation and maintenance of antiretroviral therapy (ART) for all people living with HIV (PLHIV). Interpreting quantitative patterns using qualitative data, we investigate time taken to link to care and initiate ART amongst individuals aware of their HIV-status in high HIV-prevalence urban communities in the HPTN 071 (PopART) study, a community-randomised trial of a combination HIV prevention package, including universal testing and treatment, in 21 communities in Zambia and South Africa. Data are drawn from the seven intervention communities where immediate ART irrespective if CD4 count was offered from the trial-start in 2014. Median time from HIV-diagnosis to ART initiation reduced after 2 years of delivering the intervention from 10 to 6 months in both countries but varied by gender and community of residence. Social and health system realities impact decisions made by PLHIV about ART initiation.

Indexed as

Continuity of Patient CareHealth Services AccessibilityTime-to-TreatmentAdolescentAdultAgedAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountFemaleHealthcare DisparitiesHIV InfectionsHumansMaleMiddle AgedPatient Acceptance of Health CareAnti-HIV AgentsAccessAnti-retroviral treatmentHIVLinkage to care and ARTSouthern Africa

Identifiers

PMID30415432
PMCPMC6458981

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.