Evidence map›Paper›PMID 30415407›Full record

Trial reportDigestive diseases and sciences2019

Short-Term Symptomatic Relief in Gastroesophageal Reflux Disease: A Comparative Study of Esomeprazole and Vonoprazan.

Kouichi Sakurai, Hiroko Suda, Satomi Fujie, Takayuki Takeichi, Ayako Okuda, Tetsuya Murao, Kiwamu Hasuda, Masahiro Hirano, Kiyoharu Ito, Katsuie Tsuruta and 1 more

Erratum issued 2 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05353933 nacompletednot on this mapstarted 2022, after this paper: background citation

Efficacy and Safety of Thread Embedding Acupuncture Combined With PPI in Treating GERD

TypeinterventionalSponsorUniversity of Medicine and Pharmacy at Ho Chi Minh CityRan2022 to 2022Enrolled66ConditionsGastroesophageal RefluxArmsThread embedding acupuncture, Pantoprazole 40mg
NCT06564246 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Clinical Study Evaluating The Role of Vonoprazan Versus Pantoprazole in Patients With Gastroesophageal Reflux Disease

TypeinterventionalSponsorTanta UniversityRan2024 to 2026Enrolled44ConditionsGastroesophageal Reflux Disease (GERD)ArmsVonoprazan 20 mg versus Pantoprazole 40 mg
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kouichi SakuraiHattori Clinic, 2-12-35 Shin-machi, Chuo-ku, Kumamoto City, Kumamoto, 860-0004, Japan. sakuraiko@jcom.zaq.ne.jp.
Hiroko SudaHattori Clinic, 2-12-35 Shin-machi, Chuo-ku, Kumamoto City, Kumamoto, 860-0004, Japan.
Satomi FujieHattori Clinic, 2-12-35 Shin-machi, Chuo-ku, Kumamoto City, Kumamoto, 860-0004, Japan.
Takayuki TakeichiHattori Clinic, 2-12-35 Shin-machi, Chuo-ku, Kumamoto City, Kumamoto, 860-0004, Japan.
Ayako OkudaHattori Clinic, 2-12-35 Shin-machi, Chuo-ku, Kumamoto City, Kumamoto, 860-0004, Japan.
Tetsuya MuraoHattori Clinic, 2-12-35 Shin-machi, Chuo-ku, Kumamoto City, Kumamoto, 860-0004, Japan.
Kiwamu HasudaHattori Clinic, 2-12-35 Shin-machi, Chuo-ku, Kumamoto City, Kumamoto, 860-0004, Japan.
Masahiro HiranoHirano Gastroenterology Clinic, 2-3029-2, Oonuki-machi, Nobeoka City, Miyazaki, 882-0803, Japan.
Kiyoharu ItoOzaki Clinic, 1-8 Hon-machi, Uto City, Kumamoto, 869-0431, Japan.
Katsuie TsurutaTsuruta Hospital, 10-112 Hotakubohon-machi, Higashi-ku, Kumamoto City, Kumamoto, 862-0925, Japan.
Masahiro HattoriHattori Clinic, 2-12-35 Shin-machi, Chuo-ku, Kumamoto City, Kumamoto, 860-0004, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimProton pump inhibitors and vonoprazan (a potassium-competitive acid blocker) are recommended as first-line treatments for gastroesophageal reflux disease (GERD). However, few reports have investigated the onset of action of these agents for GERD symptom relief. The present study compared the symptom relief of esomeprazole with that of vonoprazan via monitoring self-reported GERD symptoms after treatment initiation.

methodsThis was a prospective, multicenter, randomized, open-label, parallel group, comparative clinical study between esomeprazole (20 mg/day) and vonoprazan (20 mg/day) administered for 4 weeks to patients with GERD symptoms. Patients who had scores ≥ 8 on the Gastroesophageal Reflux Disease Questionnaire (GerdQ) were defined as having GERD and enrolled in this study. Sixty patients were randomly assigned to either the esomeprazole group (n = 30) or the vonoprazan group (n = 30). Treatment response rates in each drug group were evaluated according to the GerdQ. The Frequency Scale for the Symptoms of GERD (FSSG) scores from the 1st day after treatment initiation and the Global Overall Symptom (GOS) scale scores during treatment were also evaluated.

resultsAt 4 weeks, the treatment response rates for symptom relief according to the GerdQ were 88.0% in the esomeprazole group and 81.8% in the vonoprazan group. The GOS scales, which reflect the impact of GERD symptoms, were similar for both groups. The FSSG scores decreased from the 1st to the 14th day in both groups.

conclusionsThere were no substantial differences in the symptom relief between the two groups at any time point in this short-term study.

Indexed as

AdultAgedEsomeprazoleFemaleGastroesophageal RefluxHumansJapanMaleMiddle AgedProspective StudiesProton Pump InhibitorsPyrrolesRemission InductionSelf ReportSulfonamidesTime Factors1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamineEsomeprazoleProton Pump InhibitorsPyrrolesSulfonamidesEsomeprazoleGastroesophageal reflux diseaseSymptom reliefVonoprazan

Identifiers

PMID30415407
PMCPMC6440932

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.