Evidence map›Paper›PMID 30415387›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2019

Tendon morphology and mechanical properties assessed by ultrasound show change early in recovery and potential prognostic ability for 6-month outcomes.

Jennifer A Zellers, Daniel H Cortes, Ryan T Pohlig, Karin Grävare Silbernagel

Open access · greenAbstract read
In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Achilles tendon elongation after acute rupture: is it a problem? A systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Achilles Tendon Shear Wave Velocity Within a 1-Year Follow-Up After Non-Operatively Treated Rupture.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Minimal effect of scanning parameters on ultrasound shear wave elastography variability in tendons.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2024
    Article
  14. Article
  15. Measurement of Healthy and Injured Triceps Surae Morphology.Journal of visualized experiments : JoVE · 2023
    Article
  16. Article
  17. Article
  18. Reliability of Continuous Shear Wave Elastography in the Pathological Patellar Tendon.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jennifer A ZellersDepartment of Physical Therapy, University of Delaware, 540 South College Ave, Newark, DE, 19713, USA.
Daniel H CortesDepartment of Mechanical and Nuclear Engineering, Penn State University, State College, PA, USA.
Ryan T PohligCollege of Health Sciences Biostatistics Core Facility, University of Delaware, Newark, DE, USA.
Karin Grävare SilbernagelDepartment of Physical Therapy, University of Delaware, 540 South College Ave, Newark, DE, 19713, USA. kgs@udel.edu.
University of Delaware · USPennsylvania State University · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Robert E Akins · 2013 to 2026
$60.5M
Pilot Project ProgramP30GM103333 · NIGMS · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 2012 to 2016
$5.7M
continuous shear wave elastography as a diagnostic marker for tendinopathyR21AR067390 · NIAMS · UNIVERSITY OF DELAWARE · PI CORTES CORREALES, DANIEL HUMBERTO, GRAVARE SILBERNAGEL, KARIN M E · 2015 to 2016
$322k
NIAMS NIH HHS P30-GM103333NIAMS NIH HHS R21 AR067390NIAMS NIH HHS R21AR067390NIGMS NIH HHS P30 GM103333NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

purposeOptimizing tendon structural recovery during the first 12 weeks after Achilles tendon rupture is a prime target to improve patient outcomes, but a comprehensive understanding of biomarkers is needed to track early healing. The purpose of this study was to observe healing of tendon structure over time using ultrasound-based, tendon-specific measures and to identify relationships between tendon structural characteristics and clinical measures of gait and strength.

methodsTwenty-seven participants (21 males, mean (SD) age 39 (11) years) were assessed at 4, 8, 12, and 24 weeks after injury or surgery using ultrasound imaging techniques. Gait analysis and strength testing were added at the later time points.

resultsRuptured tendons had significantly lower dynamic shear modulus (p < 0.001), greater tendon cross-sectional area (p < 0.001), and greater length (p < 0.001) than the uninjured side. Dynamic shear modulus, cross-sectional area, and length were found to increase over time (p < 0.01). Tendon structure at 4 weeks post-injury [cross-sectional area symmetry (r = 0.737, p = 0.002) and dynamic shear modulus (r = 0.518, p = 0.040)] related to stance phase walking symmetry at 24 weeks.

conclusionsTendon structure assessed by ultrasound imaging changes over the first 24 weeks of healing after Achilles tendon rupture, suggesting it could be used as a biomarker to track tendon healing early in recovery. Additionally, tendon structure within the first 12 weeks relates to later walking gait and heel-rise symmetry, which may indicate that tendon structure could have prognostic value in the care of these patients. This study's clinical relevance is in its support for using ultrasound imaging to assess early patient healing and prognosticate later patient outcomes after Achilles tendon rupture. LEVEL OF EVIDENCE: Level 2, prospective cohort prognostic study.

Indexed as

Achilles TendonAdultBody Mass IndexCross-Sectional StudiesFemaleGaitHeelHumansMaleMiddle AgedPrognosisProspective StudiesRuptureShear StrengthTendon InjuriesTreatment OutcomeAnkleElastographyOutcomesUltrasound

Identifiers

PMID30415387
PMCPMC6510650
OpenAlexW2900229899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.