Evidence map›Paper›PMID 30415185›Full record

ArticleDevelopmental cognitive neuroscience2018

Do you know what I'm thinking? Temporal and spatial brain activity during a theory-of-mind task in children with autism.

Veronica Yuk, Charline Urbain, Elizabeth W Pang, Evdokia Anagnostou, Daphna Buchsbaum, Margot J Taylor

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. An Electrocortical Measure Associated with Metarepresentation Mediates the Relationship between Autism Symptoms and Theory of Mind.Clinical psychological science : a journal of the Association for Psychological Science · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Veronica YukDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada; Neurosciences and Mental Health Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada. Electronic address: veronica.yuk@sickkids.ca.
Charline UrbainDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada; Neurosciences and Mental Health Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Elizabeth W PangNeurosciences and Mental Health Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Department of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Evdokia AnagnostouDepartment of Neurology, The Hospital for Sick Children, Toronto, ON, Canada; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Daphna BuchsbaumDepartment of Psychology, University of Toronto, Toronto, ON, Canada.
Margot J TaylorDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada; Neurosciences and Mental Health Program, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada.
Hospital for Sick Children · CAUniversity of Toronto · CA

Funding

CIHR MOP-119541CIHR MOP-142379
6 · The paper itself

Abstract

The social impairments observed in children with autism spectrum disorder are thought to arise in part from deficits in theory of mind, the ability to understand other people's thoughts and feelings. To determine the temporal-spatial dynamics of brain activity underlying these atypical theory-of-mind processes, we used magnetoencephalography to characterize the sequence of functional brain patterns (i.e. when and where) related to theory-of-mind reasoning in 19 high-functioning children with autism compared to 22 age- and sex-matched typically-developing children aged 8-12 during a false-belief (theory-of-mind) task. While task performance did not differ between the two groups, children with autism showed reduced activation in the left temporoparietal junction between 300-375 and 425-500 ms, as well as increased activation in the right inferior frontal gyrus from 325 to 375 ms compared to controls. The overlap in decreased temporoparietal junction activity and increased right inferior frontal gyrus activation from 325 to 375 ms suggests that in children with autism, the right inferior frontal gyrus may compensate for deficits in the temporoparietal junction, a neural theory-of-mind network hub. As the right inferior frontal gyrus is involved in inhibitory control, this finding suggests that children with autism rely on executive functions to bolster their false-belief understanding.

Indexed as

Autism Spectrum DisorderBrainChildExecutive FunctionFemaleHumansMagnetoencephalographyMaleSpatial ProcessingTemporal LobeTheory of MindAutismChildrenFalse beliefMagnetoencephalographyTheory of mind

Identifiers

PMID30415185
PMCPMC6969351
OpenAlexW2893954840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.