ArticleNeurobiology of aging2019
Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis.Brain imaging and behavior · 2022Pooled it
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Cardiovascular risk factors and vascular neuropathological findings in primary age-related tauopathy versus Alzheimer's disease.GeroScience · 2026Article
- Pulse Pressure Impairs Cognition via White Matter Disruption.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Biological sex influences relationships between cerebral pulsatility and white matter hyperintensities in aging adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Article
- Effects of Aging, Estimated Fitness, and Cerebrovascular Status on White Matter Microstructural Health.Human brain mapping · 2025Article
- Regional network covariance patterns of white matter integrity related to cardiorespiratory fitness in healthy aging.Frontiers in aging neuroscience · 2025Article
- Global and tract-specific differences between younger and older adults in DTI measures of white matter integrity.Frontiers in aging neuroscience · 2025Article
- Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?Brain communications · 2025Review
- Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China.Frontiers in aging neuroscience · 2025Article
- Evaluating Models of the Ageing BOLD Response.Human brain mapping · 2024Article
- Regional Vulnerability of the Corpus Callosum in the Context of Cardiovascular Risk.Journal of geriatric psychiatry and neurology · 2023Article
- Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.Scientific reports · 2023Article
- Association Between Behavioral, Biological, and Genetic Markers of Cardiovascular Health and MRI Markers of Brain Aging: A Cohort Study.Neurology · 2023Article
- Multimodal fusion analysis of functional, cerebrovascular and structural neuroimaging in healthy aging subjects.Human brain mapping · 2022Article
- Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes.Reviews in endocrine & metabolic disorders · 2022Review
- Plasma aldosterone concentration is associated with white matter lesions in patients with primary aldosteronism.Endocrine · 2022Article
- Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
Cardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure, and heart rate) and white matter macrostructure (lesion volume and number) and microstructure (as measured by diffusion-weighted imaging) in the cross-sectional, population-based Cam-CAN cohort (N = 667, aged 18-88). We found that cardiovascular health and age made approximately similar contributions to white matter health and explained up to 56% of variance therein. Lower diastolic blood pressure, higher systolic blood pressure, and higher heart rate were each strongly, and independently, associated with white matter abnormalities on all indices. Body mass and exercise were associated with white matter health, both directly and indirectly via cardiovascular health. These results highlight the importance of cardiovascular risk factors for white matter health across the adult lifespan and suggest that systolic blood pressure, diastolic blood pressure, and heart rate affect white matter health via separate mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.