Evidence map›Paper›PMID 30415069›Full record

ArticleExperimental gerontology2019

Effects of ovarian hormones and estrogen receptor α on physical activity and skeletal muscle fatigue in female mice.

Christine A Cabelka, Cory W Baumann, Brittany C Collins, Nardina Nash, Gengyun Le, Angus Lindsay, Espen E Spangenburg, Dawn A Lowe

Abstract read
In one paragraph

Article in Experimental gerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
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  7. CORP: In vivo muscle strength-perspectives on the design and interpretation of preclinical animal studies.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Connecting the dots: the role of fatigue in female infertility.Reproductive biology and endocrinology : RB&E · 2024
    Review
  13. Article
  14. Ablation of skeletal muscle estrogen receptor alpha impairs contractility in male mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  15. Article
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christine A CabelkaDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota; MMC 388, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Cory W BaumannDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota; MMC 388, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Brittany C CollinsDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota; MMC 388, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Nardina NashDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota; MMC 388, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Gengyun LeDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota; MMC 388, 420 Delaware St SE, Minneapolis, MN 55455, USA.
Angus LindsayDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota; MMC 388, 420 Delaware St SE, Minneapolis, MN 55455, USA; Department of Biochemistry Molecular Biology and Biophysics, University of Minnesota, 420 Washington Ave SE, Minneapolis, MN 55455, USA.
Espen E SpangenburgEast Carolina Diabetes and Obesity Institute, Department of Physiology, Brody School of Medicine, East Carolina University, 115 Heart Drive, ECHI - Mail Stop 743, Greenville, NC 27834, USA.
Dawn A LoweDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota; MMC 388, 420 Delaware St SE, Minneapolis, MN 55455, USA. Electronic address: lowex017@umn.edu.
University of Minnesota Medical Center · USEast Carolina University · USUniversity of Minnesota · US

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Interdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8M
Musculoskeletal Training GrantT32AR050938 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CLOHISY, DENIS R · 2004 to 2020
$3.0M
NIAMS NIH HHS T32 AR007612NIAMS NIH HHS T32 AR050938NIA NIH HHS R01 AG031743NIA NIH HHS T32 AG029796NIDDK NIH HHS T32 DK091317
6 · The paper itself

Abstract

Menopause is associated with declines in physical activity and skeletal muscle strength. Physical activity is also reduced in rodents after ovariectomy (OVX) and whole-body estrogen receptor α (ERα) knockout. However, it is unclear if the effects are estradiol (E

methodsStudy 1: Forty female C57Bl/6J mice were given free access to running wheels for 2 weeks to assess baseline running and randomized into 4 treatment groups: OVX, OVX + E

resultsStudy 1: OVX + E

conclusionsCombined treatment of E

Indexed as

OvariectomyAnimalsChromatography, LiquidEstradiolEstrogen Receptor alphaEstrogensFemaleMiceMice, Inbred C57BLMice, KnockoutMuscle ContractionMuscle FatigueMuscle, SkeletalMuscle StrengthPhysical Conditioning, AnimalProgesteroneEstradiolEstrogen Receptor alphaEstrogensProgesteroneProgestinsERαEstradiolFatigueProgesteroneSkeletal muscleWheel running

Identifiers

PMID30415069
PMCPMC6331238
OpenAlexW2899536968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.