ArticleNeuroImage2019
Optimising neonatal fMRI data analysis: Design and validation of an extended dHCP preprocessing pipeline to characterise noxious-evoked brain activity in infants.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- First Application of a Novel Brain Template: Motor Training Improves Cortico-cerebellar Connectivity in Cerebellar Ataxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Functional connectivity as a prognostic biomarker for neurodevelopmental outcomes in preterm infants without severe brain injury.Brain communications · 2025Article
- Baby Brains at Work: How Task-Based Functional Magnetic Resonance Imaging Can Illuminate the Early Emergence of Psychiatric Risk.Biological psychiatry · 2023Review
- An ode to fetal, infant, and toddler neuroimaging: Chronicling early clinical to research applications with MRI, and an introduction to an academic society connecting the field.Developmental cognitive neuroscience · 2022Review
- The Developing Human Connectome Project Neonatal Data Release.Frontiers in neuroscience · 2022Article
- Maternal trait anxiety symptoms, frontolimbic resting-state functional connectivity, and cognitive development in infancy.Developmental psychobiology · 2021Article
- Functional and diffusion MRI reveal the neurophysiological basis of neonates' noxious-stimulus evoked brain activity.Nature communications · 2021Article
- MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances.Journal of magnetic resonance imaging : JMRI · 2021Review
- Multimodal Imaging Brain Markers in Early Adolescence Are Linked with a Physically Active Lifestyle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Imaging the rapidly developing brain: Current challenges for MRI studies in the first five years of life.Developmental cognitive neuroscience · 2021Review
- Naturalistic Language Input is Associated with Resting-State Functional Connectivity in Infancy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Nociception and the neonatal brain.Seminars in fetal & neonatal medicine · 2019Review
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Authors and funding
9 authors.
Funding
Abstract
The infant brain is unlike the adult brain, with considerable differences in morphological, neurodynamic, and haemodynamic features. As the majority of current MRI analysis tools were designed for use in adults, a primary objective of the Developing Human Connectome Project (dHCP) is to develop optimised methodological pipelines for the analysis of neonatal structural, resting state, and diffusion MRI data. Here, in an independent neonatal dataset we have extended and optimised the dHCP fMRI preprocessing pipeline for the analysis of stimulus-response fMRI data. We describe and validate this extended dHCP fMRI preprocessing pipeline to analyse changes in brain activity evoked following an acute noxious stimulus applied to the infant's foot. We compare the results obtained from this extended dHCP pipeline to results obtained from a typical FSL FEAT-based analysis pipeline, evaluating the pipelines' outputs using a wide range of tests. We demonstrate that a substantial increase in spatial specificity and sensitivity to signal can be attained with a bespoke neonatal preprocessing pipeline through optimised motion and distortion correction, ICA-based denoising, and haemodynamic modelling. The improved sensitivity and specificity, made possible with this extended dHCP pipeline, will be paramount in making further progress in our understanding of the development of sensory processing in the infant brain.
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