Evidence map›Paper›PMID 30414983›Full record

ArticleNeuroImage2019

Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance.

Kaitlin Cassady, Holly Gagnon, Poortata Lalwani, Molly Simmonite, Bradley Foerster, Denise Park, Scott J Peltier, Myria Petrou, Stephan F Taylor, Daniel H Weissman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Trial
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  7. Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum.Autism research : official journal of the International Society for Autism Research · 2026
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kaitlin CassadyDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Holly GagnonDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Poortata LalwaniDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Molly SimmoniteDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Bradley FoersterDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Denise ParkResearch of the Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA.
Scott J PeltierDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Myria PetrouDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Stephan F TaylorDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Daniel H WeissmanDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Rachael D SeidlerDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; School of Kinesiology, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Thad A PolkDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA. Electronic address: tpolk@umich.edu.

Funding

Dallas Lifespan Brain Study-Wave 3: Neurodegeneration & Resilience in CognitionRF1AG006265 · NIA · UNIVERSITY OF TEXAS DALLAS · PI PARK, DENISE CORTIS · 2017 to 2019
$7.1M
Investigating age-related neural dedifferentiation longitudinally and in Alzheimer’s pathologyR01AG050523 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POLK, THAD A · 2016 to 2025
$5.7M
NIA NIH HHS R01 AG050523NIA NIH HHS RF1 AG006265
6 · The paper itself

Abstract

Aging is typically associated with declines in sensorimotor performance. Previous studies have linked some age-related behavioral declines to reductions in network segregation. For example, compared to young adults, older adults typically exhibit weaker functional connectivity within the same functional network but stronger functional connectivity between different networks. Based on previous animal studies, we hypothesized that such reductions of network segregation are linked to age-related reductions in the brain's major inhibitory transmitter, gamma aminobutyric acid (GABA). To investigate this hypothesis, we conducted graph theoretical analyses of resting state functional MRI data to measure sensorimotor network segregation in both young and old adults. We also used magnetic resonance spectroscopy to measure GABA levels in the sensorimotor cortex and collected a battery of sensorimotor behavioral measures. We report four main findings. First, relative to young adults, old adults exhibit both less segregated sensorimotor brain networks and reduced sensorimotor GABA levels. Second, less segregated networks are associated with lower GABA levels. Third, less segregated networks and lower GABA levels are associated with worse sensorimotor performance. Fourth, network segregation mediates the relationship between GABA and performance. These findings link age-related differences in network segregation to age-related differences in GABA levels and sensorimotor performance. More broadly, they suggest a neurochemical substrate of age-related dedifferentiation at the level of large-scale brain networks.

Indexed as

AdultAgedAged, 80 and overAgingBrain MappingFemalegamma-Aminobutyric AcidHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleModels, NeurologicalNeural PathwaysPsychomotor PerformanceSensorimotor CortexYoung Adultgamma-Aminobutyric AcidAgingDedifferentiationGABANetwork segregationSensorimotor

Identifiers

PMID30414983
PMCPMC6338503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.