ArticlePapillomavirus research (Amsterdam, Netherlands)2018
Malignant transformation of canine oral papillomavirus (CPV1)-associated papillomas in dogs: An emerging concern?
Article in Papillomavirus research (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review.Current nutrition reports · 2022Pooled it
- Article
- A Universal and Quantitative PCR Strategy for Detection and Epidemiologic Analysis of Canine Papillomavirus (CPV).International journal of molecular sciences · 2025Article
- Performance Comparison of Genomic Best Linear Unbiased Prediction and Four Machine Learning Models for Estimating Genomic Breeding Values in Working Dogs.Animals : an open access journal from MDPI · 2025Article
- Mast Cell Density in Squamous Cell Carcinoma of Skin in Dogs and Cats.Animals : an open access journal from MDPI · 2025Article
- An update on oral manifestations of systemic disorders in dogs and cats.Frontiers in veterinary science · 2024Review
- Cell proliferation and apoptosis in canine oral papillomatosis.Veterinary research forum : an international quarterly journal · 2024Article
- Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis.Infectious agents and cancer · 2023Review
- Feline oral squamous cell carcinoma andFrontiers in veterinary science · 2023Article
- Canine and feline papillomaviruses: an update.Frontiers in veterinary science · 2023Review
- BUBR1 as a Prognostic Biomarker in Canine Oral Squamous Cell Carcinoma.Animals : an open access journal from MDPI · 2022Article
- Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors.Veterinary sciences · 2022Review
- Papillomaviral skin diseases of humans, dogs, cats and horses: A comparative review. Part 1: Papillomavirus biology and hyperplastic lesions.Veterinary journal (London, England : 1997) · 2022Review
- Papillomaviral skin diseases of humans, dogs, cats and horses: A comparative review. Part 2: Pre-neoplastic and neoplastic diseases.Veterinary journal (London, England : 1997) · 2022Review
- Non-melanoma skin cancers: physio-pathology and role of lipid delivery systems in new chemotherapeutic treatments.Neoplasia (New York, N.Y.) · 2022Review
- Pathology in Practice.Journal of the American Veterinary Medical Association · 2022Article
- Molecular detection of Papillomavirus and immunohistochemical investigation of p53 gene expressions in bovine papillomas and fibropapillomas.Archives of microbiology · 2022Article
- New insights into Canis familiaris papillomaviruses genetics and biology: Is the genetic characterization of CPV types and their variants an important clinical issue?Genetics and molecular biology · 2022Article
- Localization and genotyping of canine papillomavirus in canine inverted papillomas.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Disorder predispositions and protections of Labrador Retrievers in the UK.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine oral papillomavirus (CPV1, also known as COPV), the most common cause of non-neoplastic papillomas, has not been shown to cause squamous cell carcinomas (SCC). Furthermore, malignant transformation of benign papillomas to SCC has only been reported in a single group of dogs with severe combined immunodeficiency infected with CPV2. Here, we report a series of 7 dogs with benign CPV1-associated papillomas with histologic evidence of CPV1 causing malignant transformation to carcinoma in situ and ultimately SCC. Expression of p53 and p16 proteins in CPV1-infected cells within the benign papillomas and lesions that progressed into SCC also supported an association between papillomavirus and malignant transformation. Moreover, our retrospective analysis indicated that while there have been increased numbers of viral papillomas with malignant transformation, the number of annually diagnosed canine viral papillomas has remained constant over the past decade in our laboratory. We speculate that either an altered host immunity from increased usage of immunosuppressive drugs or changing environmental factors, e.g. increase exposure to UV radiation, may cause an increased oncogenic potential of this "low-risk" virus. This study aims to raise awareness of the malignant potential of CPV1 and to encourage further investigations into the cause of this suspected change in its oncogenic potential.
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Registered trials
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