Evidence map›Paper›PMID 30414940›Full record

ArticleBiochemical pharmacology2019

Serine residues in the α4 nicotinic acetylcholine receptor subunit regulate surface α4β2

Cristian A Zambrano, Daniela Escobar, Tania Ramos-Santiago, Ian Bollinger, Jerry Stitzel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Cristian A ZambranoInstitute for Behavioral Genetics, University of Colorado Boulder, USA. Electronic address: cristian.zambrano@colorado.edu.
Daniela EscobarInstitute for Behavioral Genetics, University of Colorado Boulder, USA.
Tania Ramos-SantiagoInstitute for Behavioral Genetics, University of Colorado Boulder, USA; University of Puerto Rico, Rio Piedras.
Ian BollingerInstitute for Behavioral Genetics, University of Colorado Boulder, USA.
Jerry StitzelInstitute for Behavioral Genetics, University of Colorado Boulder, USA; Department of Integrative Physiology, University of Colorado Boulder, USA.
University of Colorado Boulder · USUniversity of Puerto Rico at Río Piedras · PR

Funding

Analysis of alpha4 nicotinic receptors using viral re-expression in alpha4 KO miceR21DA036673 · NIDA · UNIVERSITY OF COLORADO · PI STITZEL, JERRY A · 2015 to 2016
$420k
NIDA NIH HHS R21 DA036673
6 · The paper itself

Abstract

background and purposeChronic nicotine exposure upregulates α4β2 EXPERIMENTAL APPROACH: Serine residues S336, S470 and S530 in mouse α4 were mutated to alanine and then re-expressed in primary neurons from cortex, hippocampus and subcortex of α4 KO mice. Mutant and wild type α4 expressing neurons were treated with nicotine (0.1, 1 and 10 μM) and assessed for α4β2 KEY

resultsα4β2 CONCLUSIONS AND IMPLICATIONS: Effects of α4 nAChR mutants on surface upregulation varied among brain regions, suggesting that the cellular mechanism of α4β2

Indexed as

AnimalsBrainBridged Bicyclo Compounds, HeterocyclicMice, Inbred C57BLMice, KnockoutMutagenesis, Site-DirectedMutationNeuronsNicotinePyridinesReceptors, NicotinicSerineUp-RegulationBridged Bicyclo Compounds, HeterocyclicepibatidineNicotinenicotinic receptor alpha4beta2PyridinesReceptors, NicotinicSerine[(125)I]epibatidineClustersnAChRNicotineUpregulation

Identifiers

PMID30414940
PMCPMC6802496
OpenAlexW2899929160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.