Evidence map›Paper›PMID 30414851›Full record

ReviewBiochimica et biophysica acta. Gene regulatory mechanisms2019

Post-transcriptional pseudouridylation in mRNA as well as in some major types of noncoding RNAs.

Hironori Adachi, Meemanage D De Zoysa, Yi-Tao Yu

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Gene regulatory mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 64 citations in OpenAlex.

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  15. m6A-TSHub: Unveiling the Context-specific mGenomics, proteomics & bioinformatics · 2023
    Article
  16. Review
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  19. Review
  20. [Role of PNPT1 in cardiomyocyte apoptosis induced by oxygen-glucose deprivation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hironori AdachiUniversity of Rochester Medical Center, Department of Biochemistry and Biophysics, Center for RNA Biology, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Meemanage D De ZoysaUniversity of Rochester Medical Center, Department of Biochemistry and Biophysics, Center for RNA Biology, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Yi-Tao YuUniversity of Rochester Medical Center, Department of Biochemistry and Biophysics, Center for RNA Biology, 601 Elmwood Avenue, Rochester, NY 14642, USA. Electronic address: yitao_yu@urmc.rochester.edu.
University of Rochester Medical Center · US

Funding

Expanding the genetic code by targeted pseudouridylationR01GM104077 · NIGMS · UNIVERSITY OF ROCHESTER · PI YU, YI-TAO · 2012 to 2015
$1.2M
Regulation of telomerase activity and aging by 2'-O-methylation in telomerase RNAR21AG039559 · NIA · UNIVERSITY OF ROCHESTER · PI YU, YI-TAO · 2012 to 2013
$412k
NIA NIH HHS R21 AG039559NIGMS NIH HHS R01 GM104077
6 · The paper itself

Abstract

Pseudouridylation is a post-transcriptional isomerization reaction that converts a uridine to a pseudouridine (Ψ) within an RNA chain. Ψ has chemical properties that are distinct from that of uridine and any other known nucleotides. Experimental data accumulated thus far have indicated that Ψ is present in many different types of RNAs, including coding and noncoding RNAs. Ψ is particularly concentrated in rRNA and spliceosomal snRNAs, and plays an important role in protein translation and pre-mRNA splicing, respectively. Ψ has also been found in mRNA, but its function there remains essentially unknown. In this review, we discuss the mechanisms and functions of RNA pseudouridylation, focusing on rRNA, snRNA and mRNA. We also discuss the methods, which have been developed to detect Ψs in RNAs. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.

Indexed as

RNA Processing, Post-TranscriptionalAnimalsHumansPseudouridineRNA, MessengerRNA, UntranslatedPseudouridineRNA, MessengerRNA, Untranslated

Identifiers

PMID30414851
PMCPMC6401265
OpenAlexW2900391652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.