Evidence map›Paper›PMID 30414733›Full record

ArticleMayo Clinic proceedings2018

Health Literacy and 1-Year Mortality: Mechanisms of Association in Adults Hospitalized for Cardiovascular Disease.

Lindsay S Mayberry, Jonathan S Schildcrout, Kenneth A Wallston, Kathryn Goggins, Amanda S Mixon, Russell L Rothman, Sunil Kripalani, Vanderbilt Inpatient Cohort Study

Abstract read
In one paragraph

Article in Mayo Clinic proceedings, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  12. No Healthcare Utilization and Death.Journal of general internal medicine · 2022
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  18. Association between health literacy and mortality: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2021
    Review
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Lindsay S MayberryDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN; Center for Health Behavior and Health Education, Vanderbilt University Medical Center, Nashville, TN; Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN; Center for Effective Health Communication, Vanderbilt University Medical Center, Nashville, TN. Electronic address: lindsay.mayberry@vumc.org.
Jonathan S SchildcroutDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
Kenneth A WallstonCenter for Health Services Research, Vanderbilt University Medical Center, Nashville, TN; Center for Effective Health Communication, Vanderbilt University Medical Center, Nashville, TN; School of Nursing, Vanderbilt University, Nashville, TN.
Kathryn GogginsCenter for Health Services Research, Vanderbilt University Medical Center, Nashville, TN; Center for Effective Health Communication, Vanderbilt University Medical Center, Nashville, TN; Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, TN.
Amanda S MixonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN; Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN; Geriatric Research Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, TN.
Russell L RothmanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN; Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN; Center for Effective Health Communication, Vanderbilt University Medical Center, Nashville, TN.
Sunil KripalaniDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN; Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN; Center for Effective Health Communication, Vanderbilt University Medical Center, Nashville, TN; Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, TN.
Vanderbilt Inpatient Cohort Study

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Health Literacy, Hospital Discharge, and Cardiovascular OutcomesR01HL109388 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KRIPALANI, SUNIL · 2011 to 2015
$3.3M
Targeting Family Behaviors to Improve Diabetes Management among Adults with Type 2 DiabetesK01DK106306 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAYBERRY, LINDSAY S. · 2015 to 2018
$568k
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS R01 HL109388NIDDK NIH HHS K01 DK106306
6 · The paper itself

Abstract

objectiveTo test theorized patient-level mediators in the causal pathway between health literacy (HL) and 1-year mortality in adults with cardiovascular disease (CVD). PATIENTS AND

methodsA total of 3000 adults treated at Vanderbilt University Hospital from October 11, 2011, through December 18, 2015, for acute coronary syndrome or acute decompensated heart failure (ADHF) participated in the Vanderbilt Inpatient Cohort Study. Participants completed a bedside-administered survey and consented to health record review and longitudinal follow-up. Multivariable mediation models examined the direct and indirect effects of HL (a latent variable with 4 indicators) with 1-year mortality after discharge (dichotomous). Hypothesized mediators included social support, health competence, health behavior, comorbidity index, type of CVD diagnosis, and previous-year hospitalizations.

resultsOf the 2977 patients discharged from the hospital (60% male; mean age, 61 years; 83% non-Hispanic white, 37% admitted for ADHF), 17% to 23% had inadequate HL depending on the measure, and 10% (n=304) died within 1 year. The total effect of lower HL on 1-year mortality (adjusted odds ratio [AOR]=1.31; 95% CI, 1.01-1.69) was decomposed into an indirect effect (AOR=1.50; 95% CI, 1.35-1.67) via the mediators and a nonsignificant direct effect (AOR=0.87; 95% CI, 0.66-1.14). Each SD decrease in HL was associated with an absolute 3.2 percentage point increase in the probability of 1-year mortality via mediators admitted for ADHF, comorbidities, health behavior, health competence, and previous-year hospitalizations (listed by contribution to indirect effect).

conclusionPatient-level factors link low HL and mortality. Health competence and health behavior are modifiable mediators that could be targeted by interventions post hospitalization for CVD.

Indexed as

Health Knowledge, Attitudes, PracticeHealth LiteracyAcute Coronary SyndromeFemaleHeart FailureHospitalizationHumansMaleMiddle AgedProspective StudiesRisk FactorsSocioeconomic FactorsSurveys and Questionnaires

Identifiers

PMID30414733
PMCPMC6299453

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.