Evidence map›Paper›PMID 30414629›Full record

Observational studyThe Journal of pediatrics2019

Thirteen-Year Outcomes in Very Preterm Children Associated with Diffuse Excessive High Signal Intensity on Neonatal Magnetic Resonance Imaging.

Ines M Mürner-Lavanchy, Hiroyuki Kidokoro, Deanne K Thompson, Lex W Doyle, Jeanie L Y Cheong, Rod W Hunt, Terrie E Inder, Peter J Anderson

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ines M Mürner-LavanchyMonash Institute of Cognitive and Clinical Neurosciences, Monash University, Australia; Department of Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Hiroyuki KidokoroDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Deanne K ThompsonDepartment of Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia.
Lex W DoyleDepartment of Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia; Department of Obstetrics and Gynecology, The Royal Women's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Jeanie L Y CheongDepartment of Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia; Department of Obstetrics and Gynecology, The Royal Women's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Rod W HuntDepartment of Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia.
Terrie E InderDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Peter J AndersonMonash Institute of Cognitive and Clinical Neurosciences, Monash University, Australia; Department of Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia. Electronic address: peter.j.anderson@monash.edu.

Funding

Neurobehavioral Impairments in Preterm Children - A Longitudinal MR StudyR01HD058056 · NICHD · WASHINGTON UNIVERSITY · PI INDER, TERRIE E · 2008 to 2011
$1.9M
NICHD NIH HHS R01 HD058056
6 · The paper itself

Abstract

objectiveTo investigate the association between white matter diffuse excessive high signal intensity (DEHSI) on neonatal magnetic resonance imaging in very preterm infants and neurobehavioral outcomes at the age of 13 years. STUDY

designMagnetic resonance images of very preterm children (<30 weeks gestational age or <1250 g birth weight) were evaluated at term-equivalent age with DEHSI classified into 5 grades. Additionally, visibility of the posterior periventricular crossroads was assessed. General intelligence, memory, attention, executive function, motor abilities, and behavior were examined in 125 children at age 13 years and related to DEHSI grades using linear regression.

resultsDEHSI was detected in 93% of infants; 21% grade 1, 22% grade 2, 32% grade 3, and 18% grade 4. Neurobehavioral outcomes were similar for all DEHSI groups. There was weak evidence that higher DEHSI grades related to higher verbal IQ and attention and that lower DEHSI grades related to better planning ability. Adjustment for gestational age, birth weight standard score, and sex further weakened these effects. Only 12 children had invisible posterior crossroads and showed slightly poorer outcomes at 13 years of age.

conclusionsThere was little evidence that neonatal DEHSI serves as a sensitive biomarker for later impairment. Further investigation on the importance of invisible posterior periventricular crossroads in larger samples is needed.

Indexed as

Magnetic Resonance ImagingAdolescentBehavior Rating ScaleChildFemaleFollow-Up StudiesGestational AgeHumansImage Processing, Computer-AssistedInfant, Extremely PrematureInfant, NewbornInfant, Premature, DiseasesInfant, Very Low Birth WeightLongitudinal StudiesMaleNeuropsychological Testscognitionmagnet resonance imagingneurobehaviorprematurity

Identifiers

PMID30414629
PMCPMC8898561

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.