ArticleMicrobial cell factories2018
Enhanced biosynthesis of arbutin by engineering shikimate pathway in Pseudomonas chlororaphis P3.
Article in Microbial cell factories, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- De novo biosynthesis of β-Arbutin in Komagataella phaffii based on metabolic engineering strategies.Microbial cell factories · 2024Article
- High-yield production of β-arbutin by identifying and eliminating byproducts formation.Applied microbiology and biotechnology · 2023Article
- Recent Developments in the Biological Activities, Bioproduction, and Applications ofMolecules (Basel, Switzerland) · 2023Review
- Article
- Recent Progress on Feasible Strategies for Arbutin Production.Frontiers in bioengineering and biotechnology · 2022Review
- The Effect of Arbutin on The Expression of Tumor SuppressorCell journal · 2021Article
- Tyrosinase Inhibitory Activity of Soybeans Fermented withAntioxidants (Basel, Switzerland) · 2020Article
- Identification of new arylamine N-acetyltransferases and enhancing 2-acetamidophenol production in Pseudomonas chlororaphis HT66.Microbial cell factories · 2020Article
- Engineering a Synthetic Pathway for Gentisate inFrontiers in bioengineering and biotechnology · 2020Article
- Chemical and Biocatalytic Routes to ArbutinMolecules (Basel, Switzerland) · 2019Review
- Metabolic engineering of microorganisms for production of aromatic compounds.Microbial cell factories · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundArbutin is a plant-derived glycoside with potential antioxidant, antibacterial and anti-inflammatory activities. Currently, it is mainly produced by plant extraction or enzymatic processes, which suffers from expensive processing cost and low product yield. Metabolic engineering of microbes is an increasingly powerful method for the high-level production of valuable biologicals. Since Pseudomonas chlororaphis has been widely engineered as a phenazine-producing platform organism due to its well-characterized genetics and physiology, and faster growth rate using glycerol as a renewable carbon source, it can also be engineered as the cell factory using strong shikimate pathway on the basis of synthetic biology.
resultsIn this work, a plasmid-free biosynthetic pathway was constructed in P. chlororaphis P3 for elevated biosynthesis of arbutin from sustainable carbon sources. The arbutin biosynthetic pathway was expressed under the native promoter P
conclusionsThe results suggested that the construction of plasmid-free synthetic pathway displays a high potential for improved biosynthesis of arbutin and other shikimate pathway derived biologicals in P. chlororaphis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.