Evidence map›Paper›PMID 30414398›Full record

SynthesisArchives of physical medicine and rehabilitation2019

Transcranial Direct Current Stimulation in Pediatric Motor Disorders: A Systematic Review and Meta-analysis.

Ghazala T Saleem, Jewel E Crasta, Beth S Slomine, Gabriela Lucila Cantarero, Stacy J Suskauer

2 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of physical medicine and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05670522 nacompletednot on this mapstarted 2020, after this paper: background citation

Transcranial Direct Current Stimulation Versus Virtual Reality on Gait in Children With Spastic Diplegia

TypeinterventionalSponsorBeni-Suef UniversityRan2020 to 2021Enrolled40ConditionsCerebral PalsyArmsTranscranial direct current stimulation, Virtual reality
NCT05762796 narecruitingnot on this mapstarted 2024, after this paper: background citation

Assessing the Efficacy of Alterations in Subcortical-Cortical Functional Connectivity From Transcranial Direct Current Stimulation in Older Children After Mild Traumatic Brain Injury

TypeinterventionalSponsorState University of New York at BuffaloRan2024 to 2027Enrolled10ConditionsBrain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive ImpairmentArmstDCS in Youth with mild traumatic brain injury
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ghazala T SaleemKennedy Krieger Institute, Baltimore, MD; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD.
Jewel E CrastaKennedy Krieger Institute, Baltimore, MD; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD.
Beth S SlomineKennedy Krieger Institute, Baltimore, MD; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD; Department of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine D Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD.
Gabriela Lucila CantareroDepartment of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD.
Stacy J SuskauerKennedy Krieger Institute, Baltimore, MD; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address: suskauer@kennedykrieger.org.
Johns Hopkins Medicine · USJohns Hopkins University · USKennedy Krieger Institute · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Research Training in Rehabilitation for Brain Injury and Neurological DisabilityT32HD007414 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Amy J. Bastian · 1991 to 2026
$6.3M
NCATS NIH HHS UL1 TR001079NICHD NIH HHS T32 HD007414
6 · The paper itself

Abstract

objectiveTo systematically examine the safety and effectiveness of transcranial direct current stimulation (tDCS) interventions in pediatric motor disorders. DATA SOURCES: PubMed, EMBASE, Cochrane, CINAHL, Web of Science, and ProQuest databases were searched from inception to August 2018. STUDY SELECTION: tDCS randomized controlled trials (RCTs), observational studies, conference proceedings, and dissertations in pediatric motor disorders were included. Two authors independently screened articles based on predefined inclusion criteria. DATA EXTRACTION: Data related to participant demographics, intervention, and outcomes were extracted by 2 authors. Quality assessment was independently performed by 2 authors. DATA SYNTHESIS: A total of 23 studies involving a total of 391 participants were included. There was no difference in dropout rates between active (1 of 144) and sham (1 of 144) tDCS groups, risk difference 0.0, 95% confidence interval (-.05 to .04). Across studies, the most common adverse effects in the active group were tingling (17.2%), discomfort (8.02%), itching (6.79%), and skin redness (4%). Across 3 studies in children with cerebral palsy, tDCS significantly improved gait velocity (MD=.23; 95% confidence interval [0.13-0.34]; P<.0005), stride length (MD=0.10; 95% confidence interval [0.05-0.15]; P<.0005), and cadence (MD=15.7; 95% confidence interval [9.72-21.68]; P<.0005). Mixed effects were found on balance, upper extremity function, and overflow movements in dystonia.

conclusionBased on the studies reviewed, tDCS is a safe technique in pediatric motor disorders and may improve some gait measures and involuntary movements. Research to date in pediatric motor disorders shows limited effectiveness in improving balance and upper extremity function. tDCS may serve as a potential adjunct to pediatric rehabilitation; to better understand if tDCS is beneficial for pediatric motor disorders, more well-designed RCTs are needed.

Indexed as

AdolescentCerebral PalsyChildFemaleHumansMaleMotor DisordersObservational Studies as TopicRandomized Controlled Trials as TopicTranscranial Direct Current StimulationTreatment OutcomeYoung AdultChildrenMotor disordersRehabilitationReviewTranscranial direct current stimulation

Identifiers

PMID30414398
PMCPMC7927962
OpenAlexW2899612915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.