Evidence map›Paper›PMID 30414301›Full record

ArticleEuropean journal of neurology2019

Comparing two classification schemes for seizures and epilepsy in rural China.

F Wang, Z Chen, I Davagnanam, C Hoskote, D Ding, W Wang, B Yang, Y Wang, T Wang, W Li and 2 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Classifying epilepsy pragmatically: Past, present, and future.Journal of the neurological sciences · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 5 countries.

F WangDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Z ChenDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0002-1888-6917
I DavagnanamAcademic Department of Neuroradiology, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK.
C HoskoteLysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK.
D DingFudan University, Shanghai, China.
W WangBeijing Neurosurgical Institute, Beijing, China.
B YangJiaozuo People's Hospital, Henan, China.
Y WangNingxia Medical University, Ningxia, China.
T WangJincheng Emergency Medical Rescue Center, Jincheng, China.
W LiAffiliated Second Hospital, Hebei Medical University, Hebei, China.
J W SanderNIHR University College London Hospitals, Biomedical Research Centre, UCL Institute of Neurology, London, UK.
P KwanDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
The Royal Melbourne Hospital · AUBeijing Institute of Neurosurgery · CNFudan University · CNHebei Medical University · CNJiaozuo University · CNNational Hospital for Neurology and Neurosurgery · GBNingxia Medical University · CNShanxi Jincheng Anthracite Mining Group (China) · CNUCL Biomedical Research Centre · GBUniversity College London · GB

Funding

Validation of clinical assessment tools for population genetic studies of epilepsR21NS069223 · NINDS · CHINESE UNIVERSITY OF HONG KONG · PI BAUM, LAWRENCE, CHERNY, STACEY S · 2010 to 2011
$272k
Department of Health 2016YFC0904400NINDS NIH HHS R21 NS069223NINDS NIH HHS R21NS069223-01
6 · The paper itself

Abstract

background and purposeThe International League against Epilepsy (ILAE) updated the classifications of seizures and epilepsies in 2017. The 2017 classifications were compared with the 1980s classifications in rural China.

methodsPeople with epilepsy receiving treatment under the National Epilepsy Control Programme were recruited from rural areas in China. Their seizures and epileptic syndrome were classified using the 1980s ILAE classification system and then re-classified according to the 2017 system. Differences in seizure, epilepsy and aetiology classifications were identified.

resultsA total of 597 individuals (58% males, aged 6-78 years) were included. Amongst them 535 (90%) had a single seizure type, 57 (9.55%) had two types and five (0.84%) had three. There was complete agreement between the 1981 and 2017 classifications for the 525 individuals with focal seizures. Seizures originally classified as generalized in 10 of 65 individuals were re-classified as unknown in the 2017 classification. Compared to the 1980s classifications, the proportion of individuals with unknown seizures and unknown epilepsy increased from 1.2% (7/597) to 2.8% (17/597, P = 0.002), and unknown aetiology increased from 32% (189/597: 182 cryptogenic and seven unclassified) to 39% (230/597; P < 0.001) in the 2017 classifications.

conclusionsThe 1980s and 2017 classifications had 100% agreement in classifying focal seizures and epilepsy in rural China. A small but significant proportion of generalized seizures and epilepsy and aetiologies classified in the old classifications were re-classified to unknown in the new classifications. These results highlight the need for improvement in clinical evaluation of people with epilepsy in resource-poor settings.

Indexed as

AdolescentAdultAgedChildChinaEpilepsyFemaleHumansMaleMiddle AgedRural PopulationSeizuresYoung Adultaetiologyclassificationepilepsy syndromesruralterminology

Identifiers

PMID30414301
PMCPMC6365184
OpenAlexW2900035284

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.