ArticleEvolution; international journal of organic evolution2019
Gene exchange between two divergent species of the fungal human pathogen, Coccidioides.
Article in Evolution; international journal of organic evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- From soil to clinic: current advances in understandingMicrobiology and molecular biology reviews : MMBR · 2024Review
- Admixture in the fungal pathogen Blastomyces.Genetics · 2024Article
- Temporal Variation in Introgressed Segments' Length Statistics Computed from a Limited Number of Ancient Genomes Sheds Light on Past Admixture Pulses.Molecular biology and evolution · 2023Article
- Genetic Diversity of Human Fungal Pathogens.Current clinical microbiology reports · 2023Article
- Coccidioides Species: A Review of Basic Research: 2022.Journal of fungi (Basel, Switzerland) · 2022Review
- KLFDAPC: a supervised machine learning approach for spatial genetic structure analysis.Briefings in bioinformatics · 2022Article
- Evolution of the human pathogenic lifestyle in fungi.Nature microbiology · 2022Review
- A chromosomal-level reference genome of the widely utilized Coccidioides posadasii laboratory strain "Silveira".G3 (Bethesda, Md.) · 2022Article
- Mitochondrial genomes of the human pathogens Coccidioides immitis and Coccidioides posadasii.G3 (Bethesda, Md.) · 2021Article
- Endemic and Other Dimorphic Mycoses in The Americas.Journal of fungi (Basel, Switzerland) · 2021Review
- Article
- Comparative genomics revealed adaptive admixture inMicrobial genomics · 2021Article
- Article
- Differential Thermotolerance Adaptation between Species ofJournal of fungi (Basel, Switzerland) · 2020Article
- Higher Gene Flow in Sex-Related Chromosomes than in Autosomes during Fungal Divergence.Molecular biology and evolution · 2020Article
- Fantastic yeasts and where to find them: the hidden diversity of dimorphic fungal pathogens.Current opinion in microbiology · 2019Review
- Article
- Fungal species boundaries in the genomics era.Fungal genetics and biology : FG & B · 2019Review
- Improved Reference Genome Sequence ofMicrobiology resource announcements · 2019Article
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6 authors.
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Abstract
The fungal genus Coccidioides is composed of two species, Coccidioides immitis and Coccidioides posadasii. These two species are the causal agents of coccidioidomycosis, a pulmonary disease also known as valley fever. The two species are thought to have shared genetic material due to gene exchange in spite of their long divergence. To quantify the magnitude of shared ancestry between them, we analyzed the genomes of a population sample from each species. Next, we inferred what is the expected size of shared haplotypes that might be inherited from the last common ancestor of the two species and find a cutoff to find what haplotypes have conclusively been exchanged between species. Finally, we precisely identified the breakpoints of the haplotypes that have crossed the species boundary and measure the allele frequency of each introgression in this sample. We find that introgressions are not uniformly distributed across the genome. Most, but not all, of the introgressions segregate at low frequency. Our results show that divergent species can share alleles, that species boundaries can be porous, and highlight the need for a systematic exploration of gene exchange in fungal species.
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