Evidence map›Paper›PMID 30414087›Full record

ReviewMolecular neurobiology2019

Nootropic and Anti-Alzheimer's Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer's Neuropathology.

Md Sahab Uddin, Abdullah Al Mamun, Md Tanvir Kabir, Md Jakaria, Bijo Mathew, George E Barreto, Ghulam Md Ashraf

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Article
  3. Synthesis of Novel 7-Phenyl-2,3-Dihydropyrrolo[2,1-Molecules (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Effects of Acute Ashwagandha Ingestion on Cognitive Function.International journal of environmental research and public health · 2022
    Article
  9. Neuroinflammation: A Potential Risk for Dementia.International journal of molecular sciences · 2022
    Review
  10. Frontiers in pharmacology · 2022
    Review
  11. Review
  12. Review
  13. Review
  14. Journal of fungi (Basel, Switzerland) · 2021
    Article
  15. Article
  16. Saudi journal of biological sciences · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Md Sahab UddinDepartment of Pharmacy, Southeast University, Dhaka, Bangladesh. msu-neuropharma@hotmail.com.ORCID http://orcid.org/0000-0002-0805-7840
Abdullah Al Mamun *Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Md Tanvir Kabir *Department of Pharmacy, BRAC University, Dhaka, Bangladesh.
Md JakariaDepartment of Applied Life Science, Konkuk University, Chungju, Republic of Korea.
Bijo MathewDivision of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, India.
George E BarretoDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, DC, Colombia.
Ghulam Md AshrafKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. ashraf.gm@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medicinal plants are the backbone of modern medicine. In recent times, there is a great urge to discover nootropic medicinal plants to reverse cognitive dysfunction owing to their less adverse effects. Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by the inevitable loss of cognitive function, memory and language impairment, and behavioral disturbances, which turn into gradually more severe. Alzheimer's has no current cure, but symptomatic treatments are available and research continues. The number of patients suffering from AD continues to rise and today, there is a worldwide effort under study to find better ways to alleviate Alzheimer's pathogenesis. In this review, the nootropic and anti-Alzheimer's potentials of 6 medicinal plants (i.e., Centella asiatica, Clitoria ternatea, Crocus sativus, Terminalia chebula, Withania somnifera, and Asparagus racemosus) were explored through literature review. This appraisal focused on available information about neuroprotective and anti-Alzheimer's use of these plants and their respective bioactive compounds/metabolites and associated effects in animal models and consequences of its use in human as well as proposed molecular mechanisms. This review progresses our existing knowledge to reveal the promising linkage of traditional medicine to halt AD pathogenesis. This analysis also avowed a new insight to search the promising anti-Alzheimer's drugs.

Indexed as

Plants, MedicinalAlzheimer DiseaseAnimalsHumansNootropic AgentsPlant ExtractsRandomized Controlled Trials as TopicNootropic AgentsPlant ExtractsAlzheimer’s diseaseCognitive enhancersMedicinal plantsNeurofibrillary tanglesNootropicsSenile plaques

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.