Observational studyJournal of neurovirology2019
Enhanced facilitation and diminished inhibition characterizes the pronociceptive endogenous pain modulatory balance of persons living with HIV and chronic pain.
Observational study in Journal of neurovirology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Living with HIV and Insomnia: Implications for sleep quality, experimental pain sensitivity, and clinical pain severity.The journal of pain · 2026Observational
- Distress is positively associated with induced secondary hyperalgesia in people with suppressed HIV.The journal of pain · 2026Article
- Distress is positively associated with induced secondary hyperalgesia in people with suppressed HIV.medRxiv : the preprint server for health sciences · 2025Article
- High-risk alcohol consumption is associated with mitochondrial damage-associated molecular patterns in people living with HIV.Drug and alcohol dependence reports · 2025Article
- Quantitative sensory testing for pain: What exactly are we measuring?Current opinion in psychology · 2025Review
- Examining associations among daily discrimination, psychosocial risk factors, and pain outcomes in people with chronic low back pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Sex Differences in Pain and Its Treatment.Handbook of experimental pharmacology · 2023Review
- The Experience of BIPOC Living with Chronic Pain in the USA: Biopsychosocial Factors that Underlie Racial Disparities in Pain Outcomes, Comorbidities, Inequities, and Barriers to Treatment.Current pain and headache reports · 2023Review
- Sleep Disturbances and Chronic Pain in People with HIV: Implications for HIV-Associated Neurocognitive Disorders.Current sleep medicine reports · 2022Article
- Neuropathogenesis of HIV and emerging therapeutic targets.Expert opinion on therapeutic targets · 2022Review
- Temporal Summation in Fibromyalgia Patients: Comparing Phasic and Tonic Paradigms.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Temporal summation of mechanical pain prospectively predicts movement-evoked pain severity in adults with chronic low back pain.BMC musculoskeletal disorders · 2021Article
- Sex and Gender are Not the Same: Why Identity Is Important for People Living with HIV and Chronic Pain.Journal of pain research · 2020Article
- Article
- Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain.Molecular painArticle
- Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain.Molecular painArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Chronic pain in persons living with HIV (PLWH) may be related to alterations in endogenous pain modulatory processes (e.g., high facilitation and low inhibition of nociception) that promote exaggerated pain responses, known as hyperalgesia, and central nervous system (CNS) sensitization. This observational study examined differences in endogenous pain modulatory processes between 59 PLWH with chronic pain, 51 PLWH without chronic pain, and 50 controls without HIV or chronic pain. Quantitative sensory testing for temporal summation (TS) of mechanical and heat pain as well as conditioned pain modulation (CPM) were used to assess endogenous pain facilitatory and inhibitory processes, respectively. Associations among TS, CPM, and self-reported clinical pain severity were also examined in PLWH with chronic pain. Findings demonstrated significantly greater TS of mechanical and heat pain for PLWH with chronic pain compared to PLWH without chronic pain and controls. CPM effects were present in controls, but not in either PLWH with or without chronic pain. Among PLWH with chronic pain, greater TS of mechanical pain was significantly associated with greater average clinical pain severity. Results of this study suggest that enhanced facilitation and diminished inhibition characterizes the pronociceptive endogenous pain modulatory balance of persons living with HIV and chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.