Evidence map›Paper›PMID 30414009›Full record

ArticleEJNMMI research2018

In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by

Niklas Verloh, Ingo Einspieler, Kirsten Utpatel, Karin Menhart, Stefan Brunner, Frank Hofheinz, Jörg van den Hoff, Philipp Wiggermann, Matthias Evert, Christian Stroszczynski and 2 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles.European journal of nuclear medicine and molecular imaging · 2024
    Article
  5. Clinical value of [Japanese journal of radiology · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Staging Liver Fibrosis by Fibroblast Activation Protein Inhibitor PET in a Human-Sized Swine Model.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Diagnostic performance of quantitative and qualitative parameters for the diagnosis of aortic graft infection using [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  14. 18F-FDG-PET/CT Evaluation of Indeterminate Adrenal Masses in Noncancer Patients.The Journal of clinical endocrinology and metabolism · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Comparison ofMolecular imaging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Niklas VerlohDepartment of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany. niklas.verloh@ukr.de.ORCID http://orcid.org/0000-0002-8424-5827
Ingo EinspielerDepartment of Radiology, University Hospital Regensburg, Regensburg, Germany.
Kirsten UtpatelDepartment of Pathology, University Regensburg, Regensburg, Germany.
Karin MenhartDepartment of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany.
Stefan BrunnerDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
Frank HofheinzHelmholtz-Zentrum Dresden-Rossendorf, PET Center, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
Jörg van den HoffHelmholtz-Zentrum Dresden-Rossendorf, PET Center, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
Philipp WiggermannDepartment of Radiology, University Hospital Regensburg, Regensburg, Germany.
Matthias EvertDepartment of Pathology, University Regensburg, Regensburg, Germany.
Christian StroszczynskiDepartment of Radiology, University Hospital Regensburg, Regensburg, Germany.
Dirk HellwigDepartment of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany.
Jirka GrosseDepartment of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany.
University Hospital Regensburg · DEHelmholtz-Zentrum Dresden-Rossendorf · DEUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to assess the value of MATERIALS AND

methods

resultsPatients with liver fibrosis or cirrhosis (≥ F1; LBR 1.53 ± 0.35) showed a significant higher LBR than patients with normal liver parenchyma (F0, 1.08 ± 0.23; P = 0.004). In direct comparison, LBR increased up to the advanced stage of liver fibrosis (F2; 2.00 ± 0.40) and decreased until liver cirrhosis is reached (F4, 1.32 ± 0.14).

conclusionFunctional changes in liver parenchyma during liver fibrosis/cirrhosis affect hepatic glucose metabolism and significantly differ between stages of liver fibrosis/cirrhosis, classified according to the METAVIR scoring system, as demonstrated by LBR quantification by

Indexed as

18F-FDG PET/CTFDG kineticsHepatic metabolismLiver cirrhosisLiver fibrosisMETAVIR score

Identifiers

PMID30414009
PMCPMC6226405
OpenAlexW2900038295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.