ArticleEuropean radiology2019
Detection of intralabyrinthine abnormalities using post-contrast delayed 3D-FLAIR MRI sequences in patients with acute vestibular syndrome.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02529475 (Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS)
Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Labyrinthine Abnormalities on MRI in Untreated Otosclerosis: Prevalence and Clinical Relevance.The Laryngoscope · 2026Observational
- Optimal MRI protocol for acute unilateral vestibulopathy: 3D-fsFLAIR vs 3D-fsT1WI at multiple post-contrast time points.European radiology · 2026Article
- Deep Learning-Based Inner Ear Subregion Segmentation in 3D T2-Weighted MRI Using Label-Preserving Data Augmentation.NMR in biomedicine · 2026Article
- The value of post-contrast delayed three-dimensional fluid-attenuated inversion recovery MRI in the diagnosis of unilateral vestibulopathy manifesting as episodic vestibular syndrome.Quantitative imaging in medicine and surgery · 2026Article
- Utility and Challenges of Imaging in Peripheral Vestibular Disorder Diagnosis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Delayed 3D-FLAIR MRI and vestibular recovery in unilateral acute vestibular syndrome.Journal of neurology · 2025Article
- Lesion Location and Possible Etiology of Acute Unilateral Vestibulopathy.International journal of general medicine · 2025Article
- Four-hour-delayed 3D-FLAIR MRIs in patients with acute unilateral peripheral vestibulopathy.Annals of clinical and translational neurology · 2024Article
- Selective otolithic dysfunction in patients presenting with acute spontaneous vertigo: consideration based on MRI.Frontiers in neurology · 2024Article
- Bilaterally positive head-impulse tests can differentiate AICA infarction from labyrinthitis.Frontiers in neurology · 2024Article
- The value of postcontrast delayed 3D fluid-attenuated inversion recovery MRI in the diagnosis of unilateral peripheral vestibular dysfunction.Quantitative imaging in medicine and surgery · 2023Article
- Infliximab for the Treatment of Inflammatory Labyrinthitis: A Retrospective Cohort Study.Journal of clinical medicine · 2023Article
- Extracellular Vesicles in Inner Ear Therapies-Pathophysiological, Manufacturing, and Clinical Considerations.Journal of clinical medicine · 2022Review
- Acute unilateral vestibulopathy/vestibular neuritis: Diagnostic criteria.Journal of vestibular research : equilibrium & orientation · 2022Article
- Construction of an MRI-based decision tree to differentiate autoimmune and autoinflammatory inner ear disease from chronic otitis media with sensorineural hearing loss.Scientific reports · 2021Article
- Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy.Journal of neuroinflammation · 2021Article
- MRI contribution for the detection of endolymphatic hydrops in patients with superior canal dehiscence syndrome.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Clinical characteristics in unilateral vestibular atelectasis.Journal of neurology · 2021Article
- MRI With Gadolinium as a Measure of Blood-Labyrinth Barrier Integrity in Patients With Inner Ear Symptoms: A Scoping Review.Frontiers in neurology · 2021Article
- Advanced Imaging of the Vestibular Endolymphatic Space in Ménière's Disease.Frontiers in surgery · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose3D-FLAIR sequences with delayed acquisition after contrast medium injection have demonstrated new insights into blood-labyrinthine barrier (BLB) abnormalities in various diseases. The aim of this study was to assess the BLB in patients referred with unilateral acute vestibular syndrome (UAVS). MATERIALS AND
methodsIn this retrospective multicenter imaging study, we performed 3D-FLAIR and steady-state free precession (SSFP) sequences 4 h after contrast medium administration in 26 healthy volunteers and in 30 patients with UAVS. Two radiologists, blinded to the clinical data, independently assessed the asymmetrical enhancement of the labyrinthine structures and the vestibular nerve on 3D-FLAIR sequences, and the signal of the labyrinthine structures on SSFP sequences. Inter-reader agreement tests were performed.
resultsAn asymmetrical enhancement of the semicircular canals was observed in 26 out of 30 ears (86.6%, p < 0.001) and never observed in healthy subjects. An asymmetrical enhancement of the vestibular nerve was never observed in either patients or healthy subjects. An asymmetrical enhancement of the cochlea was observed on the 3D-FLAIR sequence in 6 out of 30 ears only in the patients' group (20%, p = 0.03) and always associated with an enhancement of at least one semicircular canal. A low signal on SSFP sequences was observed only in 11 out of 30 symptomatic ears (36.7%, p < 0.001), involving the utricle in 7 ears and the superior semicircular canal in 4 ears.
conclusionPatients with typical UAVS presented with semicircular canal enhancement on MRI, while an asymmetrical enhancement of the vestibular nerve was not displayed.
trial registrationNCT02529475 KEY POINTS: • Patients with typical vestibular neuronitis presented with semicircular canal enhancement on MRI in 87% of cases. • An enhancement of the vestibular nerve was never displayed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.