Evidence map›Paper›PMID 30413926›Full record

ArticleRheumatology international2019

Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept.

Elena Generali, Greta Carrara, Marinos Kallikourdis, Gianluigi Condorelli, Alessandra Bortoluzzi, Carlo A Scirè, Carlo Selmi

Abstract read
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In one paragraph

Article in Rheumatology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elena GeneraliRheumatology and Clinical Immunology, Humanitas Clinical and Research Center, via A. Manzoni 56, Rozzano, 20089, Milan, Italy.ORCID 0000-0002-5898-1767
Greta CarraraEpidemiology Unit, Italian Society for Rheumatology, Milan, Italy.ORCID 0000-0001-9752-2275
Marinos KallikourdisLaboratory of Adaptive Immunity, Humanitas Clinical and Research Center, Milan, Italy.ORCID 0000-0001-9318-3368
Gianluigi CondorelliHumanitas University, Rozzano, Italy.ORCID 0000-0003-0481-6843
Alessandra BortoluzziUniversity of Ferrara, Ferrara, Italy.ORCID 0000-0003-2416-8134
Carlo A ScirèEpidemiology Unit, Italian Society for Rheumatology, Milan, Italy.ORCID 0000-0001-7451-0271
Carlo SelmiRheumatology and Clinical Immunology, Humanitas Clinical and Research Center, via A. Manzoni 56, Rozzano, 20089, Milan, Italy. carlo.selmi@unimi.it.ORCID 0000-0002-0323-0376
Humanitas University · ITUniversity of Ferrara · ITSocietà Italiana di Reumatologia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To estimate biologic influence on heart failure (HF) risk in rheumatoid arthritis. Retrospective cohort (RECORD Study of Italian Society for Rheumatology) study on administrative healthcare databases. We identified 2527 patients treated with either etanercept (n = 1690) or abatacept (n = 837). HF incidence rate was higher in the abatacept cohort than in the etanercept cohort with a 2.38 (95% CI 1.08-5.27) crude competing risk HR (SHR) for abatacept of developing HF, not confirmed after adjustment for prespecified confounders (SHR 1.43; 95% CI 0.51-3.98). Abatacept, compared to etanercept, is prescribed to patients with a worse cardiovascular profile but does not increase the risk of developing HF, when confounding factors are accounted for.

Indexed as

AbataceptAdultAgedArthritis, RheumatoidEtanerceptFemaleHeart FailureHospitalizationHumansMaleMiddle AgedRetrospective StudiesRiskTumor Necrosis Factor-alphaAbataceptEtanerceptTumor Necrosis Factor-alphaBiologicCardiovascularDMARDsEpidemiology

Identifiers

PMID30413926
OpenAlexW2900025409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.