Evidence map›Paper›PMID 30413811›Full record

ArticleBone marrow transplantation2019

Allogeneic stem cell transplantation for patients with relapsed or refractory T-cell lymphoma: efficacy of lymphoma-directed conditioning against advanced disease.

Gerald Wulf, Justin Hasenkamp, Wolfram Jung, Christian Wilhelm, Gerhard Held, Maike Nickelsen, Andreas Leha, Michael Pfreundschuh, Norbert Schmitz, Lorenz Trümper and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. The role of stem cell transplant (auto and allo) in PTCL and CTCL.Hematology. American Society of Hematology. Education Program · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Cytokine adsorption therapy in lymphoma-associated hemophagocytic lymphohistiocytosis and allogeneic stem cell transplantation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021
    Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Gerald WulfUniversity Medicine Göttingen, Göttingen, Germany. Gerald.wulf@med.uni-goettingen.de.
Justin HasenkampUniversity Medicine Göttingen, Göttingen, Germany.
Wolfram JungUniversity Medicine Göttingen, Göttingen, Germany.
Christian WilhelmUniversity Hospital Giessen und Marburg, Marburg, Germany.
Gerhard HeldWestpfalz-Klinikum, Kaiserslautern, Germany.
Maike NickelsenOnkologie Lerchenfeld, Hamburg, Germany.
Andreas LehaInstitut für Medizinische Statistik, Göttingen, Germany.
Michael PfreundschuhUniversitätsklinikum des Saarlands, Homburg, Germany.
Norbert SchmitzUniversitätsklinikum Münster, Münster, Germany.
Lorenz Trümper
Bertram GlassHELIOS Klinikum Berlin-Buch, Berlin, Germany.
Universitätsmedizin Göttingen · DEHelios Hospital Berlin-Buch · DEInstitut für Angewandte Statistik · DEUniversitätsklinikum des Saarlandes · DEUniversitätsklinikum Gießen und Marburg · DEUniversity Hospital Münster · DEWestpfalz Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salvage chemotherapy induces disease remissions in patients with relapsed or refractory (r/r) T-cell lymphomas, but fails to provide lasting tumor control. We analyzed the outcome after peripheral blood stem and bone marrow transplantation (PBSCT, n = 80; BMT, n = 4) from matched related (MRD, n = 22) or matched and unmatched unrelated donors (MUD and MMD, n = 53 and n = 9, respectively) following conditioning with fludarabine, busulfan, and cyclophosphamide (FBC) for 84 consecutive patients with r/r T-cell malignancies. At start of conditioning LDH was elevated in 50% of cases, and residual tumor (PD, SD, PR) was detectable in 84% of patients. In total, 38% (95% CI 33-44) of the patients were alive and disease-free after a median observation time of 14.5 (range 1.8 to 114) months. Univariate and multivariate analyses identified low ECOG status, as well as occurrence of acute GvHD as favorable factors for outcome. Lymphoma-directed conditioning with fludarabin, busulfan and cyclophosphamid (FBC-12), and allogeneic stem cell transplantation resulted in long-term survival for a proportion of patients with r/r peripheral T-cell lymphoma, including those with PR and SD only after salvage therapy.

Indexed as

AdultAgedFemaleHematopoietic Stem Cell TransplantationHumansLymphoma, T-Cell, PeripheralMaleMiddle AgedSalvage TherapySurvival AnalysisTransplantation ConditioningTransplantation, Homologous

Identifiers

PMID30413811
OpenAlexW2900424196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.