ArticleSpinal cord2019
Sepsis in mechanically ventilated patients with spinal cord injury: a retrospective analysis.
Article in Spinal cord, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diaphragmatic pacing for spinal cord injury patients: impact on weaning rate - a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Impact of early decompression surgery and injury characteristics on neurological recovery following traumatic cervical spinal cord injury.Brain & spine · 2025Article
- Postoperative prolonged mechanical ventilation in patients with surgically treated pyogenic spondylodiscitis: a surrogate endpoint for early postoperative mortality.Neurosurgical review · 2023Article
- Is procalcitonin a reliable indicator of sepsis in spinal cord injury patients: an observational cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Observational
- Pharmacological and non-pharmacological therapeutic interventions for the treatment of spinal cord injury-induced pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- High tidal volume ventilation is associated with ventilator-associated pneumonia in acute cervical spinal cord injury.The journal of spinal cord medicine · 2021Article
- Spinal cord injury-induced neurogenic bowel: A role for host-microbiome interactions in bowel pain and dysfunction.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designRetrospective analysis.
objectivesSepsis, one of the most frequent and life-threatening complications on intensive care units (ICUs), is associated with a need for mechanical ventilation (MV) as well as adverse respiratory outcomes in hospitalized individuals. However, it has poorly been investigated in patients with spinal cord injury (SCI); a population at high risk for pulmonary and infectious complications.
settingSpinal Cord Injury Center, Heidelberg University Hospital.
methodsOver a 5-year period, 182 individuals with SCI requiring MV during their ICU stay were analyzed. Data assessment included demographics, medical characteristics, focus and causative pathogen of sepsis, length of stay, weaning outcomes, and mortality.
resultsSepsis was recorded in 28 patients (15%), containing a subgroup of individuals suffering from infectious SCI and co-occurring primary sepsis with Staphylococcus aureus as the predominant microorganism. In most individuals, sepsis was found as secondary complication, which was associated with pulmonary foci, Gram-negative bacteria, and high mortality. More than 80% of individuals with secondary sepsis required induction of MV due to respiratory failure. Furthermore, respiratory failure was found to be independent of sepsis focus, spectrum of causative pathogens, SCI etiology, or severity of injury. Subsequent weaning from the respirator was prolonged in more than 90% with a high proportion of weaning failure.
conclusionsSepsis predominantly occurs as a secondary complication after SCI and is associated with detrimental outcomes. Although the lung is frequently affected as a failing organ, not all sepsis foci are pulmonary. Awareness of both actual sepsis focus and causative pathogen is central to initiate an adequate sepsis treatment.
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