ArticleScientific reports2018
Divergent short-chain fatty acid production and succession of colonic microbiota arise in fermentation of variously-sized wheat bran fractions.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- In vitro study on the role of endoxylanase-driven fibre solubilisation and fibre particle size in improving fibre fermentation in broilers.Poultry science · 2026Article
- Brewer's Spent Grain Flour: Chemical Composition, Functional Properties, and Influence on Gut Microbiota.Foods (Basel, Switzerland) · 2026Article
- Effects of Different Feeding Regimes on Rumen Microbial Composition, Functional Potential, and Fermentation Characteristics of Longdong Goats (Animals : an open access journal from MDPI · 2026Article
- Extensive particle size reduction of wheat bran increases the broiler's caecal fermentative capacity, but not bran fermentability ex vivo.Poultry science · 2026Article
- Milled and cryogenic micronised wheat bran inclusions stimulate fibre degradation and fermentation differently throughout the broiler's gastrointestinal tract.Poultry science · 2026Article
- Almond shells as a sustainable alternative to commercial insoluble fiber sources in piglets: effects on performance and digestive health.Journal of animal science · 2026Article
- Xenometabolomics reveals metabolic functional guilds unique to specific inulin subtypes in human gut microbiota cultures.mSystems · 2025Article
- Sperm Quality and Welfare of Sexually Mature Boars Supplemented with Partially Fermentable Insoluble Fiber.Life (Basel, Switzerland) · 2025Article
- Synbiotic delivery of arabinoxylan and a human-derived arabinoxylan-fermenting consortium influence mouse gut microbiome composition, metabolism, and resilience in sex-dependent ways.Food research international (Ottawa, Ont.) · 2025Article
- Microbes Matter: Exploring the Connection Between Infant Gut Microbiota and Bone Development.Calcified tissue international · 2025Article
- Impact of Fermented Soy Beverages Containing Selected Vaginal Probiotics on the In Vitro Fecal Microbiota of Post-Menopausal Women.Foods (Basel, Switzerland) · 2025Article
- Impact of partially defatted black soldier fly larvae meal on coccidia-infected chickens: effects on growth performance, intestinal health, and cecal short-chain fatty acid concentrations.Journal of animal science and biotechnology · 2025Article
- Effects of Three Modification Methods on the In Vitro Gastrointestinal Digestion and Colonic Fermentation of Dietary Fiber from Lotus Leaves.Foods (Basel, Switzerland) · 2024Article
- Enrichment and characterization of human-associated mucin-degrading microbial consortia by sequential passage.FEMS microbiology ecology · 2024Article
- Interplay between particle size and microbial ecology in the gut microbiome.bioRxiv : the preprint server for biology · 2024Article
- Microbiota from human infants consuming secretors or non-secretors mothers' milk impacts the gut and immune system in mice.mSystems · 2024Article
- Interplay between particle size and microbial ecology in the gut microbiome.The ISME journal · 2024Article
- Analysis of the fermentation kinetics and gut microbiota modulatory effect of dried chicory root reveals the impact of the plant-cell matrix rationalizing its conversion in the distal colon.Microbiome research reports · 2024Article
- Differences in fine arabinoxylan structures govern microbial selection and competition among human gut microbiota.Carbohydrate polymers · 2023Article
- Perspective: Council for Responsible Nutrition Science in Session. Optimizing Health with Nutrition-Opportunities, Gaps, and the Future.Advances in nutrition (Bethesda, Md.) · 2023Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though the physical structuring of insoluble dietary fiber sources may strongly impact their processing by microbiota in the colon, relatively little mechanistic information exists to explain how these aspects affect microbial fiber fermentation. Here, we hypothesized that wheat bran fractions varying in size would be fermented differently by gut microbiota, which would lead to size-dependent differences in metabolic fate (as short-chain fatty acids; SCFAs) and community structure. To test this hypothesis, we performed an in vitro fermentation assay in which wheat bran particles from a single source were separated by sieving into five size fractions and inoculated with fecal microbiota from three healthy donors. SCFA production, measured by gas chromatography, uncovered size fraction-dependent relationships between total SCFAs produced as well as the molar ratios of acetate, propionate, and butyrate. 16S rRNA sequencing revealed that these size-dependent metabolic outcomes were accompanied by the development of divergent microbial community structures. We further linked these distinct results to subtle, size-dependent differences in chemical composition. These results suggest that physical context can drive differences in microbiota composition and function, that fiber-microbiota interaction studies should consider size as a variable, and that manipulating the size of insoluble fiber-containing particles might be used to control gut microbiome composition and metabolic output.
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