ArticleNature communications2018
Active intermixing of indirect and direct neurons builds the striatal mosaic.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism.bioRxiv : the preprint server for biology · 2025Article
- Gastrin-releasing peptide signaling in the nucleus accumbens medial shell regulates neuronal excitability and motivation.Nature communications · 2025Article
- Disorganized Striatal Functional Connectivity as a Partially Shared Pathophysiological Mechanism in Both Schizophrenia and Major Depressive Disorder: A Transdiagnostic fMRI Study.Brain topography · 2025Article
- Haploinsufficiency ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs.Nature neuroscience · 2024Article
- Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transcription factor Sp9 is a negative regulator of D1-type MSN development.Cell death discovery · 2022Article
- Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The transcription factorFrontiers in cell and developmental biology · 2022Article
- Conservation of the Direct and Indirect Pathway Dichotomy in Mouse Caudal Striatum With Uneven Distribution of Dopamine Receptor D1- and D2-Expressing Neurons.Frontiers in neuroanatomy · 2022Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression.Nature communications · 2021Article
- Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon.Cell reports · 2021Article
- Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model.Cell · 2020Article
- Using genomic resources for linkage analysis in Peromyscus with an application for characterizing Dominant Spot.BMC genomics · 2020Article
- Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.Nature communications · 2020Article
- Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development.Cell reports · 2020Article
- Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration.Frontiers in cell and developmental biology · 2020Article
- Compartmental function and modulation of the striatum.Journal of neuroscience research · 2019Review
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Authors and funding
15 authors.
Funding
Abstract
The striatum controls behaviors via the activity of direct and indirect pathway projection neurons (dSPN and iSPN) that are intermingled in all compartments. While such cellular mosaic ensures the balanced activity of the two pathways, its developmental origin and pattern remains largely unknown. Here, we show that both SPN populations are specified embryonically and intermix progressively through multidirectional iSPN migration. Using conditional mutant mice, we found that inactivation of the dSPN-specific transcription factor Ebf1 impairs selective dSPN properties, including axon pathfinding, while molecular and functional features of iSPN were preserved. Ebf1 mutation disrupted iSPN/dSPN intermixing, resulting in an uneven distribution. Such architectural defect was selective of the matrix compartment, highlighting that intermixing is a parallel process to compartment formation. Our study reveals while iSPN/dSPN specification is largely independent, their intermingling emerges from an active migration of iSPN, thereby providing a novel framework for the building of striatal architecture.
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