Evidence map›Paper›PMID 30413657›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Immuno-PET of Innate Immune Markers CD11b and IL-1β Detects Inflammation in Murine Colitis.

Nicole Dmochowska, William Tieu, Marianne D Keller, Hannah R Wardill, Chris Mavrangelos, Melissa A Campaniello, Prab Takhar, Patrick A Hughes

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Combined [European journal of nuclear medicine and molecular imaging · 2026
    Observational
  4. Review
  5. Granzyme B PET Imaging for Assessment of Disease Activity in Inflammatory Bowel Disease.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  6. Imaging Agents for PET of Inflammatory Bowel Disease: A Review.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Review
  7. Detection of IL12/23p40 via PET Visualizes Inflammatory Bowel Disease.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  8. Druggability of Targets for Diagnostic Radiopharmaceuticals.ACS pharmacology & translational science · 2023
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Scientific reports · 2020
    Article
  18. Article
  19. Toward Molecular Imaging of Intestinal Pathology.Inflammatory bowel diseases · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicole DmochowskaCentre for Nutrition and Gastrointestinal Diseases, Adelaide Medical School, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, Australia.
William TieuMolecular Imaging and Therapy Research Unit, South Australian Health and Medical Research Institute, Adelaide, Australia; and.
Marianne D KellerCentre for Nutrition and Gastrointestinal Diseases, Adelaide Medical School, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, Australia.
Hannah R WardillCentre for Nutrition and Gastrointestinal Diseases, Adelaide Medical School, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, Australia.
Chris MavrangelosCentre for Nutrition and Gastrointestinal Diseases, Adelaide Medical School, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, Australia.
Melissa A CampanielloCentre for Nutrition and Gastrointestinal Diseases, Adelaide Medical School, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, Australia.
Prab TakharMolecular Imaging and Therapy Research Unit, South Australian Health and Medical Research Institute, Adelaide, Australia; and.
Patrick A HughesCentre for Nutrition and Gastrointestinal Diseases, Adelaide Medical School, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, Australia patrick.hughes@adelaide.edu.au.
South Australian Health and Medical Research Institute · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disease of the gastrointestinal tract. The diagnosis and monitoring of IBD are reliant on endoscopy, which is invasive and does not provide information on specific mediators. Symptom flare in IBD is associated with increased activation of innate immune pathways. Immuno-PET approaches have previously demonstrated the ability to detect colitis; however, a direct comparison of antibodies targeted to innate immune mediators and cells has not been done. We aimed to compare immuno-PET of antibodies to IL-1β and CD11b against standard

Indexed as

Immunity, InnatePositron-Emission TomographyAnimalsBiological TransportBiomarkersCD11b AntigenColitisDisease Models, AnimalFluorodeoxyglucose F18ImmunoconjugatesInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLRadioisotopesBiomarkersCD11b AntigenFluorodeoxyglucose F18ImmunoconjugatesInterleukin-1betaRadioisotopesZirconiumZirconium-89colitisimmuno-PETinflammatory bowel diseaseinnate immune system

Identifiers

PMID30413657
PMCPMC6581233
OpenAlexW2900055384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.